Ipsapirone
- CAS No.
- 95847-70-4
- Chemical Name:
- Ipsapirone
- Synonyms
- Isapirone;IPSAPIRONE;Ipsapirone, 10 mM in DMSO;Benzeneethanamine,5-chloro-α-methyl-;1,2-benzisothiazol-3(2h)-one,2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-,1,;2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)benzo[d]isothiazol-3(2H)-one 1,1-dioxide;2-[4-[4-(2-PYRIMIDINYL)-1-PIPERAZINYL]BUTYL]-1,2-BENZISOTHIAZOL-3(2H)-ONE-1,1-DIOXIDE;1,2-Benzisothiazol-3(2H)-one, 2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, 1,1-dioxide
- CBNumber:
- CB2254702
- Molecular Formula:
- C19H23N5O3S
- Molecular Weight:
- 401.48
- MDL Number:
- MFCD00866976
- MOL File:
- 95847-70-4.mol
- MSDS File:
- SDS
| Melting point | 137-138° |
|---|---|
| Boiling point | 629.8±65.0 °C(Predicted) |
| Density | 1.345±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | Soluble to 10 mM in DMSO |
| form | Powder |
| pka | 7.69±0.10(Predicted) |
| color | White to off-white |
| FDA UNII | 6J9B11MN0K |
Ipsapirone price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22075 | Ipsapirone ≥98% | 95847-70-4 | 5mg | $79 | 2023-06-20 | Buy |
| Cayman Chemical | 22075 | Ipsapirone ≥98% | 95847-70-4 | 10mg | $109 | 2023-06-20 | Buy |
| Cayman Chemical | 22075 | Ipsapirone ≥98% | 95847-70-4 | 25mg | $255 | 2023-06-20 | Buy |
| Cayman Chemical | 22075 | Ipsapirone ≥98% | 95847-70-4 | 50mg | $469 | 2023-06-20 | Buy |
| Tocris | 1869 | Ipsapirone ≥99%(HPLC) | 95847-70-4 | 10 | $107 | 2021-12-16 | Buy |
Ipsapirone Chemical Properties,Uses,Production
Uses
Ipsapirone is a selective SR-1A agonist.
Uses
Anti-anxiety agent .
Definition
ChEBI: 1,1-dioxo-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzothiazol-3-one is a N-arylpiperazine.
Biological Activity
Selective 5-HT 1A receptor agonist (K i = 10 nM). Anxiolytic in vivo .
in vivo
Ipsapirone inhibits induced by 8-OH-DPAT and 5-methoxydimethyltryptamine (agonists of 5-HT1A receptors) behavioural effects (flat body posture and forepaw treading) in normal and reserpinized rats[1].
Ipsapirone (2.5-80 mg/kg), given alone to rats induces a slight flattening of body posture (~ 1 point at the highest dose) and a mild hind limb abduction observed at doses 2.5-80 mg/kg. Ipsapirone given alone at low doses (2.5-10 mg/kg i.p.) does not significantly change the body temperature in rats and mice, but decreased it in both those species at high doses (35 mg/kg i.p.) by ca. 2-2.5℃[1].
| Animal Model: | Male Albino-Swiss mice (18-24 g) and male Wistar rats (160-200 g)[1]. |
| Dosage: | 5 and 10 mg/kg. |
| Administration: | IP 30 min before 8-OH-DPAT and 5-MeODMT injections. |
| Result: | Behavioural responses (flat body posture, forepaw treading) to 8-OH-DPAT (5 mg/kg s.c.) in rats were antagonized by Ipsapirone (5 and 10 mg/kg i.p.). |
IC 50
5-HT1A Receptor
storage
Room temperature
Ipsapirone Preparation Products And Raw materials
Raw materials
Preparation Products
Ipsapirone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32285 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 | |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3474 | 58 |
| DebyeTec.com Inc. | 18086626237 18086626237 | sales@debyesci.com | China | 3116 | 56 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
View Lastest Price from Ipsapirone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-27 | Ipsapirone
95847-70-4
|
US $48.00-118.00 / mg | 99.01% | 10g | TargetMol Chemicals Inc. |
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- Ipsapirone
95847-70-4
- US $48.00-118.00 / mg
- 99.01%
- TargetMol Chemicals Inc.