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ChemicalBook >> CAS DataBase List >>BESTATIN HYDROCHLORIDE

BESTATIN HYDROCHLORIDE

CAS No.
65391-42-6
Chemical Name:
BESTATIN HYDROCHLORIDE
Synonyms
BESTATIN HCL;Bestatin.HCI;Ubenimex HCl;Ubenimex-d7 HCl;BESTATIN HYDROCHLORIDE;Ubenimex hydrochloride;HYDROCHLORIDE,Ubenimex;Bestatin research grade;BESTATIN HYDROCHLORIDE USP/EP/BP;Bestatin-d7 HCl (Ubenimex-d7 HCl)
CBNumber:
CB2172341
Molecular Formula:
C16H25ClN2O4
Molecular Weight:
344.83
MDL Number:
MFCD00058004
MOL File:
65391-42-6.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33

BESTATIN HYDROCHLORIDE Properties

Melting point 216-218 °C
storage temp. 2-8°C
solubility H2O: 25 mg/mL, clear, colorless
form White to off-white powder.
color White
Water Solubility Soluble in water (4 mg/ml, warm), DMSO (>25 mg/ml), methanol, acetic acid, dimethyl formamide, and 100% ethanol.
BRN 4628066
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO, distilled water, or ethanol may be stored at -20° for up to 1 month.
InChIKey XGDFITZJGKUSDK-UDYGKFQRSA-N
CAS DataBase Reference 65391-42-6(CAS DataBase Reference)
FDA UNII BY7Y2JX7NQ

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  3
F  3-10
HS Code  29242995

BESTATIN HYDROCHLORIDE price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B8385 Bestatin hydrochloride ≥98% (HPLC) 65391-42-6 1mg $76.9 2024-03-01 Buy
Sigma-Aldrich B8385 Bestatin hydrochloride ≥98% (HPLC) 65391-42-6 5mg $164 2024-03-01 Buy
Sigma-Aldrich 10874515001 Bestatin [(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucinehydrochloride 65391-42-6 10mg $244 2022-05-15 Buy
TCI Chemical B4000 N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Hydrochloride >97.0%(HPLC) 65391-42-6 25mg $194 2024-03-01 Buy
Alfa Aesar J60384 Bestatin hydrochloride, 98% 65391-42-6 5mg $87.65 2024-03-01 Buy
Product number Packaging Price Buy
B8385 1mg $76.9 Buy
B8385 5mg $164 Buy
10874515001 10mg $244 Buy
B4000 25mg $194 Buy
J60384 5mg $87.65 Buy

BESTATIN HYDROCHLORIDE Chemical Properties,Uses,Production

Description

Bestatin HCl (65391-42-6) inhibits leucine aminopeptidase and aminopeptidases B and N. Inhibits leukotriene A4 hydrolase. Displays immunostimulant activity via activation of macrophages and T lymphocytes. Displays antitumor activity.

Uses

Bestatin is an inhibitor of amino peptidases and a potent, irreversible inhibitor of LTA4 hydrolase. It inhibits the amino peptidase activity of LTA4 hydrolase with a Ki value of 201 nM. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation. It does not inhibit carboxypeptidases.

Uses

competitive aminopeptidase B inhibitor

Uses

Bestatin Hydrochloride is an inhibitor of aminopeptidases, LAP3, and leukotriene A4 hydrolase. It is the salt form of Bestatin (B319500).

Uses

Bestatin has been used as a protease inhibitor for the purification of his-tagged Tau protein.

Definition

ChEBI: Bestatin (hydrochloride) is a peptide.

General Description

Chemical structure: amino acid derivatives

Biochem/physiol Actions

A metalloprotease inhibitor selective for aminopeptidase. Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase. It inhibits aminopeptidase B at 60 nM (using arginine-β-naphthylamide as substrate) and leucine aminopeptidase at 20 nM (leucine-β-naphthylamide as substrate). It showed no inhibition of aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, or themolysin. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation.

in vivo

in a mouse dorsal air sac assay, oral administration of bestatin (100-200 mg/kg/day) showed a significant inhibitory activity against the melanoma cell-induced angiogenesis. bestatin also inhibited the tube-like formation of human umbilical vein endothelial cells (huvecs). furthermore, after the orthotopic implantation of b16-bl6 melanoma cells into mice, bestatin administration (50-100 mg/kg/day, i.p) reduced the number of vessels oriented towards the established primary tumor mass on the dorsal side of mice [1].

References

1) Orning et al. (1991), Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes; J. Biol. Chem., 266 1375 2) Wang et al. (2010), The effect of different species aminopeptidase N structure on the activity screening of aminopeptidase N inhibitor; Biol. Pharm. Bull., 33 1658

BESTATIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 161)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3002 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5906 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22784 58
Baoji Guokang Bio-Technology Co., Ltd. 		0917-3909592 13892490616 gksales1@gk-bio.com China 9312 58
Henan Alfa Chemical Co., Ltd 		China 10947 58

View Lastest Price from BESTATIN HYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BESTATIN HYDROCHLORIDE pictures 2024-12-20 BESTATIN HYDROCHLORIDE
65391-42-6
 US $30.00 / kg 1kg 99% 5000kg/week Hebei Zhuanglai Chemical Trading Co.,Ltd
Bestatin hydrochloride pictures 2024-11-19 Bestatin hydrochloride
65391-42-6
 US $47.00-108.00 / mg 98% 10g TargetMol Chemicals Inc.
Bestatin hydrochloride pictures 2021-07-13 Bestatin hydrochloride
65391-42-6
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
N-[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL]-L-LEUCINE HYDROCHLORIDE N-(3R-AMINO-2S-HYDROXY-1-OXO-4-PHENYLBUTYL)-L-LEUCINE, MONOHYDROCHLORIDE [(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-L-LEUCINE HCL [(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-L-LEUCINE HYDROCHLORIDE (AMINO-2-HYDROXY-4-PHENYLBUTYRYL)-L-LEUCINE HYDROCHLORIDE BESTATIN HCL BESTATIN HYDROCHLORIDE N-(2S,3R-3-AMINO-2-HYDROXY-4-PHENYLBUTY- RYL)-L-LEUCINE HCL Bestatin.HCI N-(3-Amino-2-hydroxy-1-oxo-4-phenylbutyl)-L-leucine monohydrochloride (S)-2-((2S,3R)-3-aMino-2-hydroxy-4-phenylbutanaMido)-4-Methylpentanoic acid hydrochloride L-Leucine,N-[(2S,3R)-3-aMino-2-hydroxy-1-oxo-4-phenylbutyl]-, hydrochloride (1:1) Ubenimex hydrochloride Bestatin research grade Ubenimex Hydrochloride [for Biochemical Research] Bestatin-d7 HCl (Ubenimex-d7 HCl) Ubenimex-d7 HCl HYDROCHLORIDE,Ubenimex Bestatin hydrochloride, ≥98% (HPLC) N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Hydrochloride > BESTATIN HYDROCHLORIDE USP/EP/BP Ubenimex-d7 HClQ: What is Ubenimex-d7 HCl Q: What is the CAS Number of Ubenimex-d7 HCl (4S,5R)-5-amino-4-hydroxy-2-(2-methylpropyl)-3-oxo-6-phenyl-D-norleucine hydrochloride N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucine hydrochloride (S)-2-((2S,3R)-3-Amino-2-hydroxy-4-phenylbutanamido)-4-methylpentanoic acid hydrochloride[Ubenimex Hydrochloride Ubenimex HCl，Bestatin hydrochloride Ubenimex HCl 65391-42-6 C16H24N2O4ClH C16HH24N2O4xHCL Antibiotics A-F Antibiotics A to Z Antibiotics BioChemical peptides Bestatin inhibitor Pepetides