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ChemicalBook >> CAS DataBase List >>THYMOQUINONE

THYMOQUINONE

CAS No.
490-91-5
Chemical Name:
THYMOQUINONE
Synonyms
Thymoquinon;5-ISOPROPYL-2-METHYL-1,4-BENZOQUINONE;NSC 2228;THYMOQUINONE;thymolquinone;AURORA KA-6714;Semen Nigellae;Nigellae Semen。;Thymoquinone,99%;Thymoquinone >
CBNumber:
CB1483664
Molecular Formula:
C10H12O2
Molecular Weight:
164.2
MDL Number:
MFCD00001602
MOL File:
490-91-5.mol
MSDS File:
SDS
Last updated:2024-12-18 14:07:02

THYMOQUINONE Properties

Melting point 45-47 °C(lit.)
Boiling point 230-232 °C(lit.)
Density 1.0326 (rough estimate)
refractive index 1.5155 (estimate)
Flash point 219 °F
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly, Heated), Ethanol (Slightly), Methanol (Slightly)
form Solid
color Light Orange to Dark Yellow
Stability Light Sensitive
LogP 2.200
CAS DataBase Reference 490-91-5(CAS DataBase Reference)
FDA UNII O60IE26NUF
EPA Substance Registry System 2,5-Cyclohexadiene-1,4-dione, 2-methyl-5-(1-methylethyl)- (490-91-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  GU5330000
HS Code  29146990
NFPA 704
0
2 0

THYMOQUINONE price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 274666 Thymoquinone ≥98% 490-91-5 1g $63.2 2024-03-01 Buy
Sigma-Aldrich 03416 Thymoquinone analytical standard 490-91-5 100mg $71 2024-03-01 Buy
TCI Chemical T0795 Thymoquinone >98.0%(GC) 490-91-5 1g $47 2024-03-01 Buy
TCI Chemical T0795 Thymoquinone >98.0%(GC) 490-91-5 5g $172 2024-03-01 Buy
Cayman Chemical 15039 Thymoquinone ≥98% 490-91-5 1g $41 2024-03-01 Buy
Product number Packaging Price Buy
274666 1g $63.2 Buy
03416 100mg $71 Buy
T0795 1g $47 Buy
T0795 5g $172 Buy
15039 1g $41 Buy

THYMOQUINONE Chemical Properties,Uses,Production

Description

Thymoquinone is an allergen In different cedar species.

Chemical Properties

orange to brown crystals

Uses

Thymoquinone is a phytochemical compound found in the plant Nigella sativa. Thymoquinone has antioxidant effects and has been shown to protect against heart, liver and kidney damage in animal studies, as well as having possible anti-cancer effects. Thymoquinone also has analgesic and anticonvulsant effects in animal models. Thymoquinone is an angiogenesis inhibitor. An IRAK1 inhibitor with in vivo and in vitro anti-inflammatory activities. Dyes and metabolites.

Definition

ChEBI: Thymoquinone is a member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity. It has a role as an anti-inflammatory agent, an antioxidant, an adjuvant, an antineoplastic agent, a cardioprotective agent, an antidepressant and a plant metabolite.

Contact allergens

Thymoquinone is an allergen in different cedar species, Cupressaceae family, such as incense cedar (Calocedrus decurrens Florin) used for pencils, chests or toys, and western cedar (Thuja plicata Donn.) as used for hard real- izations such as construction or boats.

Anticancer Research

The black cumin (Nigella sativa) that has a long history of medicinal use contains aphytochemical called thymoquinone (2-methyl-5-isopropyl-1,4-benzoquinone)(Padhye et al. 2008; Khan et al. 2011). In the regions of Southeastern Asia, Africa,Arab and the Mediterranean, the black cumin seeds have a notable history in traditionalmedicine practices. In ancient Egypt, Greece and Turkey, black cumin seedswere often used to treat many diseases and ailments (Padhye et al. 2008; Salih et al.2009; Khan et al. 2011; Ahmad et al. 2013). The Nigella sativa plant seeds and oilare used for medicinal purposes, and they are known for their hepatoprotective,renal-protective, antimicrobial, antidiabetic, anticancer, antihypertensive, analgesic,anti-inflammatory, immunomodulatory, spasmolytic, gastro-protective, bronchodilativeand antioxidant activities (Salih et al. 2009; Khan et al. 2011; Ahmad et al.2013). Recently, Barkat et al. (2017) reported that administration of thymoquinoneto MDA-MB-231 acts on cell cycle and inhibits progression from G1 to S phase bytargeting the cell cycle-related proteins such as cyclin D1, cyclin E and p27. It alsoexhibits histone deacetylase (HDAC) inhibitory effects, targets p21 and Maspin andinduces pro-apoptotic gene, Bax, and downregulates anti-apoptotic gene Bcl-2(Barkat et al. 2017).
Thymoquinone is the primary bioactive constituent of seed oil of Nigella sativa. It is a chemopreventiveagent and suppresses the proliferation of breast, colorectal, leukemia, osteosarcoma,ovarian, and pancreatic cancer cells. It suppresses TNF-inducedactivationof NF-κB in a time- and dose-dependent manner and the subsequent inhibition ofIκBα kinase activation, IκBα degradation, phosphorylation, p65 nuclear translocation,and phosphorylation. It specifically suppresses the nuclear p65 and recombinantp65 direct binding to DNA. It also downregulates the expression ofNF-κB-regulated antiapoptotic (survivin, IAP1, Bcl-xL, XIAP IAP2, Bcl-2), proliferative(cyclin D1, c-myc, and COX-2), and angiogenic (VEGF and MMP-9) geneproducts. It suppresses the activation of ERK and AKT pathways and blocks in vitroand in vivo angiogenesis (Aggarwal et al. 2008).

Anticancer Research

Thymoquinone acts on cell cycleand inhibits progression from G1 toS phase by targeting the cellcycle-related proteins such as cyclinD1, cyclin E and p27.It also exhibits histone deacetylase(HDAC) inhibitory effects andtargets p21 and Maspin.Induces pro-apoptotic gene, Bax,and downregulates anti-apoptoticgene Bcl-2
Barkat et al.(2017)

89-83-8
490-91-5
Synthesis of THYMOQUINONE from Thymol

THYMOQUINONE Preparation Products And Raw materials

Global( 215)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Weibang Biotechnology Co., Ltd 		+8615531157085 abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12835 58
HangZhou RunYan Pharma Technology Co.,LTD. 		+8618882027439 sales2@runyanpharma.com China 302 58
Hebei Jingbo New Material Technology Co., Ltd 		+8619931165850 hbjbtech@163.com China 1000 58
Hebei Saisier Technology Co., LTD 		+86-18400010335 +86-18034520335 admin@hbsaisier.cn China 1015 58
BINBO BIOLOGICAL CO.,LTD 		+8618629063126 info@binbobiological.com China 423 58
Hebei Longbang Technology Co., LTD 		+86-18633929156 +86-18633929156 admin@hblongbang.com China 941 58
HebeiShuoshengImportandExportco.,Ltd 		+86-18532138899 +86-18532138899 L18532138899@163.com China 939 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58

View Lastest Price from THYMOQUINONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Thymoquinone pictures 2024-12-22 Thymoquinone
490-91-5
 US $0.00-0.00 / g 10000g 99% HPLC 1000kg HangZhou RunYan Pharma Technology Co.,LTD.
THYMOQUINONE pictures 2024-12-20 THYMOQUINONE
490-91-5
 US $0.00-0.00 / kg 1kg ≥98% UV 1000kg Changsha Staherb Natural Ingredients Co., Ltd.
THYMOQUINONE pictures 2024-12-20 THYMOQUINONE
490-91-5
 US $6.00 / kg 1kg 99% 2000KG/Month HebeiShuoshengImportandExportco.,Ltd
  • Thymoquinone pictures
  • Thymoquinone
    490-91-5
  • US $0.00-0.00 / g
  • 99% HPLC
  • HangZhou RunYan Pharma Technology Co.,LTD.
  • THYMOQUINONE pictures
  • THYMOQUINONE
    490-91-5
  • US $0.00-0.00 / kg
  • ≥98% UV
  • Changsha Staherb Natural Ingredients Co., Ltd.
  • THYMOQUINONE pictures
  • THYMOQUINONE
    490-91-5
  • US $6.00 / kg
  • 99%
  • HebeiShuoshengImportandExportco.,Ltd
4-dione,2-methyl-5-(1-methylethyl)-5-cyclohexadiene-1 4-dione,5-isopropyl-2-methyl-5-cyclohexadiene-1 5-Isopropyl-2-methyl-p-benzoquinone p-Cymene-2,5-dione thymolquinone P-MENTHA-3,6-DIENE-2,5-DIONE TIMTEC-BB SBB008296 THYMOQUINONE 2-ISOPROPYL-5-METHYL-1,4-BENZOQUINONE 2-METHYL-5-ISO-PROPYLBENZOQUINONE AURORA KA-6714 2-isopropyl-5-methyl-p-benzoquinone 2-METHYL-5-(1-METHYLETHYL)-2,5-CYCLOHEXANDIENE-1,4-DIONE Thymoquinone,99% 3,6-p-menthadiene-2,5-dione Thymoquinone,2-Isopropyl-5-methyl-1,4-benzoquinone Thymoquinone, 2-Methyl-5-(prop-2-yl)cyclohexa-2,5-diene-1,4-dione 5-Isopropyl-2-methyl-1,4-benzoquinone p-Mentha-3,6-diene-2,5-dione NSC 2228 2,5-Cyclohexadiene-1,4-dione,2-Methyl-5-(1-Methylethyl)- 2-isopropyl-5-Methylcyclohexa-2,5-diene-1,4-dione Semen Nigellae Thymoquinone, >=98% Black seed extract Semen Nigellae extract 2,5-Cyclohexadiene-1,4-dione, 5-isopropyl-2-methyl- 2-Isopropyl-5-methylbenzo-1,4-quinone 2-Isopropyl-5-methylbenzoquinone 2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione 2-Methyl-5-isopropyl-1,4-benzoquinone 2-Methyl-5-isopropyl-p-benzoquinone 2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione Nigellae Semen。 THYMOQUINONE NSC 2228 Thymoquinone > Black grass seed P.E Nigellae Semen extract THYMOQUINONE 490-91-5 5-ISOPROPYL-2-METHYL-1,4-BENZOQUINONE Thymoquinon 5-Bromo-54-fluorobenzylamine&hydrochloride Thymoquinone (25 mg) 490-91-5 CH3C3H7C6H2O2 Benzoquinones Anthraquinones, Hydroquinones and Quinones Benzoquinones