1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
![1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Structure](CAS/20180629/GIF/1384424-80-9.gif)
- CAS No.
- 1384424-80-9
- Chemical Name:
- 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
- Synonyms
- A-1070722;A 1070722, 10 mM in DMSO;N-(7-Methoxy-4-quinolinyl)-N’-[6-(trifluoromethyl)-2-pyridinyl]urea;1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea;N-(7-Methoxy-4-quinolinyl)-N'-[6-(trifluoromethyl)-2-pyridinyl]urea;Urea, N-(7-methoxy-4-quinolinyl)-N'-[6-(trifluoromethyl)-2-pyridinyl]-;A 1070722,Glycogen synthase kinase-3,inhibit,A1070722,Inhibitor,GSK-3,Glycogen synthase kinase 3,A-1070722
- CBNumber:
- CB12751082
- Molecular Formula:
- C17H13F3N4O2
- Molecular Weight:
- 362.31
- MDL Number:
- MFCD22580422
- MOL File:
- 1384424-80-9.mol
| Boiling point | 412.5±45.0 °C(Predicted) |
|---|---|
| Density | 1.461±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble15mg/mL, clear |
| pka | 11.57±0.43(Predicted) |
| form | powder |
| color | white to beige |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-36/37/38 | |||||||||
| Safety Statements | 36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0863 | A-1070722 ≥98% (HPLC) | 1384424-80-9 | 5mg | $123 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0863 | A-1070722 ≥98% (HPLC) | 1384424-80-9 | 25mg | $425 | 2022-05-15 | Buy |
| Cayman Chemical | 29783 | A-1070722 | 1384424-80-9 | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 29783 | A-1070722 | 1384424-80-9 | 25mg | $343 | 2024-03-01 | Buy |
| Cayman Chemical | 29783 | A-1070722 | 1384424-80-9 | 1mg | $32 | 2024-03-01 | Buy |
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Chemical Properties,Uses,Production
Description
A-1070722 is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = <100 nM).
Uses
N-(7-Methoxy-4-quinolinyl)-N''-[6-(trifluoromethyl)-2-pyridinyl]urea is a neuroprotective agent and a glycogen synthase kinase-3 (GSK-3) inhibitor. GSK-3 is a conserved signaling enzyme that regulates a wide range of biological events (apoptosis, synaptic plasticity, axon formation, and neurogenesis). The enzyme has a conserved catalytic domain for binding ATP and a C-terminal domain with a conserved activation loop for the kinase activity. GSK-3 is a therapeutic target for treating neurodegenerative and psychiatric disorders.
in vivo
A 1070722 (10-20 mg/kg, 30 min before cocaine injection or 30 min prior to injection with saline (test day)) decreases spontaneous locomotion, inhibits the expression of conditioned activities but not the acquisition of conditioned activities in Cocaine-paired rats[2].
IC 50
GSK-3α: 0.6 nM (Ki); GSK-3β: 0.6 nM (Ki)
storage
Store at RT
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Preparation Products And Raw materials
Raw materials
Preparation Products
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32239 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38648 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19897 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7787 | 56 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9342 | 58 |
