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ChemicalBook--->CAS DataBase List--->1384424-80-9

1384424-80-9

1384424-80-9 Structure

1384424-80-9 Structure
IdentificationBack Directory
[Name]

1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
[CAS]

1384424-80-9
[Synonyms]

A-1070722
N-(7-Methoxy-4-quinolinyl)-N&rsquo
-[6-(trifluoromethyl)-2-pyridinyl]urea
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
N-(7-Methoxy-4-quinolinyl)-N'-[6-(trifluoromethyl)-2-pyridinyl]urea
Urea, N-(7-methoxy-4-quinolinyl)-N'-[6-(trifluoromethyl)-2-pyridinyl]-
[Molecular Formula]

C17H13F3N4O2
[MDL Number]

MFCD22580422
[MOL File]

1384424-80-9.mol
[Molecular Weight]

362.31
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO: soluble15mg/mL, clear
[form ]

powder
[color ]

white to beige
Safety DataBack Directory
[Hazard Codes ]

T
[Risk Statements ]

25-36/37/38
[Safety Statements ]

36/37/39-45
[RIDADR ]

UN 2811 6.1 / PGIII
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

A-1070722 is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = <100 nM).
[Uses]

N-(7-Methoxy-4-quinolinyl)-N''-[6-(trifluoromethyl)-2-pyridinyl]urea is a neuroprotective agent and a glycogen synthase kinase-3 (GSK-3) inhibitor. GSK-3 is a conserved signaling enzyme that regulates a wide range of biological events (apoptosis, synaptic plasticity, axon formation, and neurogenesis). The enzyme has a conserved catalytic domain for binding ATP and a C-terminal domain with a conserved activation loop for the kinase activity. GSK-3 is a therapeutic target for treating neurodegenerative and psychiatric disorders.
[storage]

Store at RT
Spectrum DetailBack Directory
[Spectrum Detail]

1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea(1384424-80-9)1HNMR
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