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ChemicalBook >> CAS DataBase List >>CD38 inhibitor 78c

CD38 inhibitor 78c

CAS No.
1700637-55-3
Chemical Name:
CD38 inhibitor 78c
Synonyms
78c;cd38-1;MDK7553;MDK 7553;MDK-7553;CD38i_78c;CD38IN-78c;CD38 IN-78c;CD38-IN-78c;Compound-78c
CBNumber:
CB04667733
Molecular Formula:
C22H27N3O3S
Molecular Weight:
413.53
MDL Number:
MOL File:
1700637-55-3.mol
Last updated:2024-11-19 23:02:33

CD38 inhibitor 78c Properties

Boiling point 589.8±50.0 °C(Predicted)
Density 1.27±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 25 mg/mL (60.46 mM; ultrasonic and warming and heat to 60°C)
form A solid
pka 3.17±0.20(Predicted)
color Light yellow to brown
InChI InChI=1S/C22H27N3O3S/c1-25-20-8-3-15(21-13-23-14-29-21)11-18(20)19(12-22(25)26)24-16-4-6-17(7-5-16)28-10-9-27-2/h3,8,11-14,16-17,24H,4-7,9-10H2,1-2H3/t16-,17-
InChIKey VJQALSOBHVEJQM-QAQDUYKDSA-N
SMILES N1(C)C2=C(C=C(C3SC=NC=3)C=C2)C(N[C@@H]2CC[C@@H](OCCOC)CC2)=CC1=O

CD38 inhibitor 78c price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC M349560 4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-Quinolinone 1700637-55-3 1mg $370 2021-12-16 Buy
DC Chemicals DC20332 CD38inhibitor78c >98% 1700637-55-3 100mg $800 2021-12-16 Buy
DC Chemicals DC20332 CD38inhibitor78c >98% 1700637-55-3 250mg $1400 2021-12-16 Buy
DC Chemicals DC20332 CD38inhibitor78c >98% 1700637-55-3 1g $2800 2021-12-16 Buy
Product number Packaging Price Buy
M349560 1mg $370 Buy
DC20332 100mg $800 Buy
DC20332 250mg $1400 Buy
DC20332 1g $2800 Buy

CD38 inhibitor 78c Chemical Properties,Uses,Production

Description

Thiazoloquin(az)olin(on)es, such as the small molecule 78c, have been identified as potent CD38 inhibitors (CD38i). CD38 inhibitor 78c is a potent, reversible, and uncompetitive inhibitor of CD38. 78c reverses age-related NAD+ decline and ameliorates several metabolic, structural, and molecular ageing features in chronologically aged and progeroid mice. The CD38 inhibitor 78c increases naturally aged mice's lifespan and health span. In addition to a 10% increase in median survival, 78c improved exercise performance, endurance, and metabolic function in mice. The effects of 78c were different between the sexes[1-2].

Uses

4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-Quinolinone is a useful compound and has been evaluated for use as CD38 inhibitors.

storage

Store at -20°C

References

[1] Thais R. Peclat. “CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging.” Aging Cell 21 4 (2022).
[2] Mariana G Tarragó. “A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline.” Cell metabolism 27 5 (2018): 1081-1095.e10.

CD38 inhibitor 78c Preparation Products And Raw materials

Raw materials

Preparation Products

CD38 inhibitor 78c Suppliers

Global( 61)Suppliers
Supplier Tel Email Country ProdList Advantage
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581 sales@chemhifuture.com China 3135 58
Hubei Chuchang Biotech Co., Ltd.
+undefined15623860702 info@chuchangbiotech.com China 116 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Henan Alfa Chemical Co., Ltd 		China 10947 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nanjing Doge Biomedical Technology Co., Ltd 		+86-25-58227606 +86-15305155328 sales@dogechemical.com China 4128 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
Hebei Miaoyin Technology Co.,Ltd 		+86-17367732028 +86-17367732028 kathy@hbyinsheng.com China 3512 58

View Lastest Price from CD38 inhibitor 78c manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CD38 inhibitor 1 pictures 2024-11-19 CD38 inhibitor 1
1700637-55-3
 US $51.00-213.00 / mg 99.86% 10g TargetMol Chemicals Inc.
CD38 inhibitor 1 pictures 2024-11-19 CD38 inhibitor 1
1700637-55-3
 US $51.00-213.00 / mg 99.86% 10g TargetMol Chemicals Inc.
CD38 pictures 2024-11-19 CD38
1700637-55-3
 US $0.00-0.00 / mg 1mg 98 100G Hubei Chuchang Biotech Co., Ltd.
  • CD38 inhibitor 1 pictures
  • CD38 inhibitor 1
    1700637-55-3
  • US $51.00-213.00 / mg
  • 99.86%
  • TargetMol Chemicals Inc.
  • CD38 inhibitor 1 pictures
  • CD38 inhibitor 1
    1700637-55-3
  • US $51.00-213.00 / mg
  • 99.86%
  • TargetMol Chemicals Inc.
  • CD38 pictures
  • CD38
    1700637-55-3
  • US $0.00-0.00 / mg
  • 98
  • Hubei Chuchang Biotech Co., Ltd.

CD38 inhibitor 78c Spectrum

CD38 inhibitor 78c CD38 inhibitor 1 2(1H)-Quinolinone, 4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)- CD38 inhibitor 1 (compound 78c) 4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-Quinolinone 4-((trans-4-(2-Methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one cd38-1 CD38 inhibitor 1,Inhibitor,inhibit,CD-38 inhibitor 1 4-[[trans-4-(2-Methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)quinolin-2(1H)-one 4- (trans 4- (2-methoxyethoxy) cyclohexyl) amino) -1-methyl-6- (thiazol-5-yl) quinoline-2 (1H) - one CD38 IN-78c CD38-IN-78c CD38IN-78c Cluster of Differentiation 38 Inhibitor Compound-78c MDK 7553 MDK7553 MDK-7553 78c CD38i_78c CD38IN-78c: CD38 inhibitor 78c 1700637-55-3