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Crospovidone

Crospovidone Struktur
CAS-Nr.
Englisch Name:
Crospovidone
Synonyma:
CBNumber:
CB9955428
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

Crospovidone Eigenschaften

L?slichkeit
Practically insoluble in water and most common organic solvents.

Sicherheit

Crospovidone Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Crospovidone is a white to creamy-white, finely divided, freeflowing, practically tasteless, odorless or nearly odorless, hygroscopic powder.

Verwenden

Pharmaceutic aid (tablet excipient).

Vorbereitung Methode

Acetylene and formaldehyde are reacted in the presence of a highly active catalyst to form butynediol, which is hydrogenated to butanediol and then cyclodehydrogenated to form butyrolactone. Pyrrolidone is produced by reacting butyrolactone with ammonia. This is followed by a vinylation reaction in which pyrrolidone and acetylene are reacted under pressure. The monomer vinylpyrrolidone is then polymerized in solution,using a catalyst.Crospovidone is prepared by a ‘popcorn polymerization’ process.

Pharmazeutische Anwendungen

Crospovidone is a water-insoluble tablet disintegrant and dissolution agent used at 2–5% concentration in tablets prepared by direct compression or wet- and dry-granulation methods. It rapidly exhibits high capillary activity and pronounced hydration capacity, with little tendency to form gels.Studies suggest that the particle size of crospovidone strongly influences disintegration of analgesic tablets. Larger particles provide a faster disintegration than smaller particles. Crospovidone can also be used as a solubility enhancer. With the technique of co-evaporation, crospovidone can be used to enhance the solubility of poorly soluble drugs. The drug is adsorbed on to crospovidone in the presence of a suitable solvent and the solvent is then evaporated. This technique results in faster dissolution rate.

Sicherheit(Safety)

Crospovidone is used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material. Shortterm animal toxicity studies have shown no adverse effects associated with crospovidone. However, owing to the lack of available data, an acceptable daily intake in humans has not been specified by the WHO.
LD50 (mouse, IP): 12g/kg

Lager

Since crospovidone is hygroscopic, it should be stored in an airtight container in a cool, dry place.

Inkompatibilit?ten

Crospovidone is compatible with most organic and inorganic pharmaceutical ingredients. When exposed to a high water level, crospovidone may form molecular adducts with some materials.

Regulatory Status

Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM injections, oral capsules and tablets; topical, transdermal, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Crospovidone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Crospovidone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 23)Lieferanten
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