3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-10-oxo-7-[[1-oxo-9-[3-(4-pentyn-1-yl)-3H-diazirin-3-yl]nonyl]oxy]-, inner salt, 4-oxide, (7R)- Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
1-palmitoyl-2-(9-(3-pent-4-ynyl-3-H-diazirin-3-yl)-nonanoyl)-
sn-glycero-3-phosphocholine (16:0-pacFA PC) might be used to label hydrogenated zwitterionic bicelles (HZB) and hydrogenated anionic bicelles (HAB).
Allgemeine Beschreibung
The pacFA lipid attached to 1-palmitoyl-
sn-glycero-3-phosphocholine, contains a photoactivable diazirine ring with a clickable alkyne group.
Biochem/physiol Actions
1-palmitoyl-2-(9-(3-pent-4-ynyl-3-H-diazirin-3-yl)-nonanoyl)-sn-glycero-3-phosphocholine (16:0-pacFA PC) may be used for a global analysis of protein–lipid interactions in living cells. pacFA acts as a precursor for the biosynthesis of bifunctional lipids. Proteins in contact with the bifunctional lipids are then cross-linked by ultraviolet (UV) irradiation of the diazirine ring. Finally, click chemistry is used to label the alkyne with a reporter molecule.
3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-10-oxo-7-[[1-oxo-9-[3-(4-pentyn-1-yl)-3H-diazirin-3-yl]nonyl]oxy]-, inner salt, 4-oxide, (7R)- Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte