Pemirolast NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Pemirolast | CAS No.: 69372-19-6 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Pemirolast |
| Description | Pemirolast is an orally active antiallergic agent that attenuates paclitaxel hypersensitivity reactions by inhibiting the release of sensory neuropeptides, and can be used for bronchial asthma and conjunctivitis research [1] - [5]. |
| In vitro | Pemirolast, at concentrations ranging from 1 μM to 1 mM, dose-dependently inhibits the release of LTC4 and ECP induced by A23187 from eosinophils, as well as PAF-induced and FMLP-induced ECP release at concentrations of 0.1 mM and 1 mM. This action of Pemirolast helps mitigate the activation of human eosinophils, thereby reducing the release of granule proteins LTQ and ECP, which is instrumental in controlling allergic diseases. However, when tested at concentrations between 100 nM and 1 mM for durations of 1 to 15 minutes, Pemirolast does not significantly impact the release of histamine from human conjunctival mast cells. Additionally, Pemirolast, within the range of 0.1 μg/mL to 0.01 mg/mL, blocks the activation of signal transduction phospholipases C and AZ in rat peritoneal mast cells. It achieves this by preventing antigen and compound 48/80 induced degranulation, consequently inhibiting the formation of 1,2-diacylglycerol and phosphatidic acid. |
| In vivo | Pemirolast effectively mitigates paclitaxel hypersensitivity reactions by hindering the release of sensory neuropeptides in rats. It demonstrates this effect by inhibiting taxel-induced pulmonary vascular hyperpermeability and rectifying the decrease in arterial PaO2 at a dose of 1 mg/kg, half an hour post a 15 mg/kg paclitaxel injection. Additionally, at the same dosage and timing, Pemirolast counteracts the taxel-induced rise in sensory neuropeptides levels (CGRP, substance P, and neurokinin A), providing further evidence of its potent anti-inflammatory properties. In separate studies, oral administration of Pemirolast (10 mg/kg/d for 4-5 days) markedly diminished cisplatin-induced kaolin intake on the third and fourth days, as well as suppressed the release of substance P in the cerebrospinal fluid (CSF) of rats, indicating its efficacy in reducing cisplatin-induced adverse effects without affecting normal feed intake. These outcomes underscore Pemirolast's therapeutic potential in managing chemotherapy-induced complications through modulation of sensory neuropeptide activity. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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