PIERICIDIN A
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- CAS-Nr.
- 2738-64-9
- Englisch Name:
- PIERICIDIN A
- Synonyma:
- SN 198E;IT-143D;piericidin;piericidinea;PIERICIDIN A;PIERICIDIN A1;SHAOGUAMYCIN B;SHAOGUANMYCIN B;piericidin(sub1);piericidin a from microbial source
- CBNumber:
- CB9758229
- Summenformel:
- C25H37NO4
- Molgewicht:
- 415.57
- MOL-Datei:
- 2738-64-9.mol
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PIERICIDIN A Eigenschaften
- Siedepunkt:
- 614.9±55.0 °C(Predicted)
- Dichte
- 1.044±0.06 g/cm3(Predicted)
- Flammpunkt:
- 85 °C
- storage temp.
- 2-8°C
- L?slichkeit
- Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
- pka
- 5.21±0.33(Predicted)
- Aggregatzustand
- liquid
- Farbe
- green-yellow
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or Ethanol may be stored at -20°C for up to 1 month.
PIERICIDIN A Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Verwenden
Piericidin A is the major analogue of a family of pyridyl antibiotics isolated from selected Streptomyces species. It is a specific, potent inhibitor of NADH-ubiquinone oxidoreductase (Complex I) that binds to ubiquinone binding site(s). Piericidin A inhibits both mitochondrial and bacterial NADH-ubiquinone oxidoreductases, binding close to NUOD-NUOB interface.
Biochem/physiol Actions
Piericidin A (PA), an insecticidal metabolite of Streptomyces mobaraensis is a potential quorum-sensing inhibitors (QSIs) that can destroy the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Hence it may be used as control agents of soft rot disease on potato tubers.
Enzyminhibitor
This reduced antibiotic (FW = 423.64 g/mol; CAS 2738-64-9; Soluble in ethanol, methanol, DMF or DMSO) is a structural analogue of ubiquinone and a partially competitive inhibitor of bacterial and mitochondrial Type-I NADH-ubiquinone oxidoreductases (or Complex I). Octahydropiericidin A also inhibits glucose dehydrogenase.
PIERICIDIN A Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
PIERICIDIN A Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 60)Lieferanten
2738-64-9()Verwandte Suche:
- ,5,7,11-tetramethyl-,(all-e)-(4s,5s)-
- 2,6,9,11-tridecatetraen-4-ol,13-(4-hydroxy-5,6-dimethoxy-3-methyl-2-pyridyl)-3
- piericidin
- piericidin(sub1)
- piericidinea
- SN 198E
- SHAOGUAMYCIN B
- SHAOGUANMYCIN B
- PIERICIDIN A
- PIERICIDIN A1
- 2,6,9,11-TRIDECATETRAEN-4-OL,13-(4-HYDROX-5,6-DIMETHOXY-3-METHYL-2-PYRIDYL)-3,5,7,11-TETRAMETHYL-(ALL-E)-(4R,5R)-(8CL)
- Piericidin A from Streptomyces mobaraensis
- PENICILLIN-STREPTOMYCIN (200X PEN-STREP)
- piericidin a from microbial source
- Piericidin A1, Shaoguamycin B, SN 198E, 2,6,9,11-Tridecatetraen-4-ol,13-(4-hydrox-5,6-dimethoxy-3-methyl-2-pyridyl)-3,5,7,11-tetramethyl-(all-E)-(4R,5R)-(8Cl), 4-Pyridinol,2-(10-hydroxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraenyl)-5,6-dimethoxy- [R-[R*,R*-(all-E)]]-3-methyl-
- (2E,4S,5S,6E,8E,11E)-13-(5,6-Dimethoxy-4-hydroxy-3-methyl-2-pyridyl)-3,5,7,11-tetramethyl-2,6,8,11-tridecatetren-4-ol
- IT-143D
- 4-PYRIDINOL,2-(10-HYDROXY-3,7,9,11-TETRAMETHYL-2,5,7,11-TRIDECATETRAENYL)-5,6-DIMETHOXY-, [R-[R*,R*-(ALL-E)]]-3-METHYL-
- ShaoguanMycin B, MT 1882-I, SN 198E, IT 143D, Piericidin A1
- 2,6,9,11-Tridecatetraen-4-ol,13-(4-hydrox-5,6-dimethoxy-3-methyl-2-pyridyl)-3,5,7,11-tetramethyl-(all-E)-(4R,5R)
- 4-Pyridinol,2-(10-hydroxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraenyl)-5,6-dimethoxy- [R-[R*,R*-(all-E)]]-3-methyl-
- 2-[(2E,4E,7E,9S,10S,11E)-10-hydroxy-3,7,9,11-tetramethyltrideca-2,4,7,11-tetraenyl]-5,6-dimethoxy-3-methyl-1H-pyridin-4-one
- 4-Pyridinol, 2-[(2E,5E,7E,9R,10R,11E)-10-hydroxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraen-1-yl]-5,6-dimethoxy-3-methyl-
- 2-((2E,5E,7E,9R,10R,11E)-10-Hydroxy-3,7,9,11-tetramethyltrideca-2,5,7,11-tetraen-1-yl)-5,6-dimethoxy-3-methylpyridin-4-ol
- 2738-64-9
- Mitochondrial Transport Inhibitors
- Cell Biology
- Cell Signaling and Neuroscience
- Apoptosis and Cell Cycle
- Antibiotics N-S
- Antibiotics
- Antibiotics A to Z
- BioChemical
- Antibiotic
