(R)-1-BOC-3-(Hydroxymethyl)piperazine
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- CAS-Nr.
- 278788-66-2
- Englisch Name:
- (R)-1-BOC-3-(Hydroxymethyl)piperazine
- Synonyma:
- tert-butyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate;(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate;tert-butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate;tert-Butyl (3R)-3-(hydroxymethyl)-1-piperazinecarboxylate;H57159;(3R)-3-(hydroxymethyL;PIPERAZINE-1-CARBOXYLIC;(R)-4-N-Boc-2-hydroxyMeth...;(3R)-3-(Hydroxymethyl)piperazine;(R)-1-Boc-3-(hyroxyMethyl)piperazine
- CBNumber:
- CB9715509
- Summenformel:
- C10H20N2O3
- Molgewicht:
- 216.28
- MOL-Datei:
- 278788-66-2.mol
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(R)-1-BOC-3-(Hydroxymethyl)piperazine Eigenschaften
- Schmelzpunkt:
- 68-70°C
- Siedepunkt:
- 322.9±22.0 °C(Predicted)
- Dichte
- 1.085±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- Chloroform (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 14.97±0.10(Predicted)
- Farbe
- White to Off-White
- InChI
- InChI=1S/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-8(6-12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m1/s1
- InChIKey
- NSILYQWHARROMG-MRVPVSSYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCN[C@@H](CO)C1
- CAS Datenbank
- 278788-66-2(CAS DataBase Reference)
(R)-1-BOC-3-(Hydroxymethyl)piperazine Chemische Eigenschaften,Einsatz,Produktion Methoden
Synthese
1,4-bis-Boc-2-hydroxymethylpiperazine (13.9 kg) and 95% ethanol (30 kg) were added to the reactor, followed by the addition of an aqueous solution (water 21 kg) of configured sodium hydroxide (3.5 kg). The reaction mixture was then heated to reflux. Once the reaction was completed, ethanol was concentrated under reduced pressure. Subsequently, 30 kg of dichloromethane was added and the mixture was separated into liquid and aqueous phases. The aqueous phase was extracted three times with 3 × 20 kg of dichloromethane, and the organic phases were combined. The resulting solution was washed once with 40 kg of a 15% aqueous sodium chloride solution and dried with anhydrous sodium sulfate. Further purification was carried out to obtain (R)-1-BOC-3-(Hydroxymethyl)piperazine.
(R)-1-BOC-3-(Hydroxymethyl)piperazine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(R)-1-BOC-3-(Hydroxymethyl)piperazine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 246)Lieferanten
- (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- (R)-4-N-BOC-2-HYDROXYMETHYL-PIPERAZINE
- (R)-1-Boc-3-hydroxymethyl-piperazine
- H57159
- (R)-4-Boc-2-hydroxymethyl-piperazine
- 1-Piperazinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3R)-
- (R)-1-Boc-3-(Hydroxymethyl)piperazine ,98%
- (R)-4-N-Boc-2-hydroxyMeth...
- (R)-1-Boc-3-(hyroxyMethyl)piperazine
- (3R)-3-(Hydroxymethyl)piperazine, N1-BOC protected
- tert-Butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate, (3R)-1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine
- (3R)-1-Boc-3-(hydroxyMethyl)-piperazine
- (3R)-3-(Hydroxymethyl)piperazine, N1-BOC protected 98%
- (3R)-3-(hydroxymethyL
- (3R)-3-(Hydroxymethyl)piperazine
- ert-butyl(3R)-3-(hydroxymethyl)piperazine-1-carboxylate
- (R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate
- tert-butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate
- tert-butyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate
- tert-Butyl (3R)-3-(hydroxymethyl)-1-piperazinecarboxylate
- PIPERAZINE-1-CARBOXYLIC
- (3R)-3-(hydroxymethyl)-1-Piperazinecarboxylic acid tert-butyl ester
- 278788-66-2
- pharmacetical
- Piperaizine
- 1
