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Pifithrin-α (PFTα)

Pifithrin-α (PFTα) Struktur
63208-82-2
CAS-Nr.
63208-82-2
Englisch Name:
Pifithrin-α (PFTα)
Synonyma:
PFTα;CS-607;CS-1772;PFTα HBr;(PFTαPifithrin-α;Zinc03874684;PIFITHRIN-ALPHA;Pifithrin-α HBr;PFT-α,Pifithrin-α
CBNumber:
CB9700743
Summenformel:
C16H19BrN2OS
Molgewicht:
367.3
MOL-Datei:
63208-82-2.mol

Pifithrin-α (PFTα) Eigenschaften

Schmelzpunkt:
192.1-192.5 °C(lit.)
storage temp. 
-20°C
L?slichkeit
DMSO: 20 mg/mL
Aggregatzustand
powder
pka
9.11(at 25℃)
Farbe
off-white
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  3
HS Code  2934.20.8000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Pifithrin-α (PFTα) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. It prevents p53-mediated apoptosis induced by cytotoxic compounds in C8 cells at 10 μM and in human umbilical vein endothelial cells at 30 μM. Pifithrin-α can also protect cells from DNA damage-induced apoptosis by a p53-independent mechanism that might involve cyclin D1.

Verwenden

Pifithrin-α has been used:
  • to study the effect of specific p53 inhibitor on p53-upregulated modulator of apoptosis (PUMA) expression after transient global cerebral ischemia (tGCI)
  • as p53 inhibitor to treat PA1 cells
  • as a tumor protein p53 (TRP53) inhibitor, to treat mouse lung epithelial-12 (MLE-12) cells

Allgemeine Beschreibung

A cell-permeable chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects normal tissues from the deleterious side effects of chemotherapy. Has been reported to protect neurons against β-amyloid peptide and glutamate-induced apoptosis.

Biologische Aktivit?t

Inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo ; protects mice from the side-effects of cancer therapy associated with p53 induction. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC 50 = 1.1 μ M).

Pifithrin-α (PFTα) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Pifithrin-α (PFTα) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 129)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289
contact@trustwe.com China 5738 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30239 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 22784 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
LEAPCHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 43340 58

  • 1-(4-METHYLPHENYL)-2-(4,5,6,7-TETRAHYDRO-2-IMINO-3(2H)-BENZOTHIAZOLYL)ETHANONE, MONOHYDROBROMIDE
  • Pifithrin-Hydrobromide
  • 2-(2-imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide
  • PFT-α,Pifithrin-α
  • Zinc03874684
  • Ethanone, 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-iMino-3(2H)-benzothiazolyl)-, MonohydrobroMide
  • PFTα hydrobroMide
  • Pifithrin-alpha . HBr
  • 2-(2-iMino-4,5,6,7-tetrahydrobenzo[d]thiazol-3(2H)-yl)-1-p-tolylethanone hydrobroMide
  • Pifithrin-α (PFTα)
  • 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone,hydrobromide
  • Ethanone, 1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-, hydrobromide (1:1)
  • 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide Pifithrin-α
  • Pifithrin Pifithrin-alpha
  • (PFT&alpha
  • 2-(2-IMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOL-3-YL)-1-P-TOLYLETHANONE, HBR
  • 1-(4-METHYLPHENYL)-2-(4,5,6,7-TETRAHYDRO-2-IMINO-3(2H)-BENZOTHIAZOLYL)ETHANONE HYDROBROMIDE
  • PIFITHRIN-ALPHA
  • PIFITHRIN-ALPHA HYDROBROMIDE
  • PFTα HBr
  • Pifithrin-α HBr
  • Pifithrin-α( PFTα) HBr
  • Pifithrin-α - CAS 63208-82-2 - Calbiochem
  • CS-607
  • PIFITHRIN HYDROBROMIDE; PIFITHRIN-Α HYDROBROMIDE; PFTΑ HYDROBROMIDE
  • CS-1772
  • Pifithrin-α hydrobromide
  • PFTα
  • Pifithrin-α
  • 2-(2-imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide USP/EP/BP
  • Pifithrin-Alpha(PFTalpha)1-(4-METHYLPHENYL)-2-(4,5,6,7-TETRAHYDRO-2-IMINO-3(2H)-BENZOTHIAZOLYL)ETHANONE, MONOHYDROBROMIDE
  • Pifithrin-α (PFTα)
  • PFTα hydrobromide
  • Pifithrin-α (PFTα) HBr
  • Pifithrin-a (PFTa)
  • 63208-82-2
  • C16H18N2OSHBr
  • Apoptosis Inhibitors
  • Apoptosis and Cell Cycle
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Inhibitors
  • Caspases/Apoptosis
  • Inhibitor
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