N-Fluoren-2-ylacetamid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R45:Kann Krebs erzeugen.
R22:Gesundheitssch?dlich beim Verschlucken.
S-S?tze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Chemische Eigenschaften
WHITE TO YELLOW-BROWN CRYSTALLINE POWDER
Verwenden
N-(2-Fluorenyl)acetamide (2-Acetamidofluorene, 2-AAF), a genotoxic carcinogen, is used to induce liver cancer in animal models such as the 2-AAF/partial hepatectomy rat. 2-AAF may be used to study the mechanism of liver carcinogenesis and as a reference material during its identification or quantitation.
Definition
ChEBI: The parent of the class of 2-acetamidofluorenes, being an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. It is a carcinogenic and mutagenic derivative of fluorene.
Vorbereitung Methode
2-Acetylaminofluorene is produced for research purposes
only with an estimated U.S. annual usage of less than 20
lb. It was originally developed as a possible insecticide
but has never been used for this purpose after discovery of its
carcinogenicity. It is now almost exclusively used in the
laboratory studies as a model carcinogen and mutagen.
Allgemeine Beschreibung
White powder or light beige solid.
Air & Water Reaktionen
Insoluble in water.
Reaktivit?t anzeigen
2-ACETAMIDOFLUORENE is incompatible with acids, bases and oxidizing agents. Ozone and chlorinating agents oxidize 2-ACETAMIDOFLUORENE .
Health Hazard
2-Acetylaminofluorene (AAF) is
a potent carcinogen in dogs, hamsters, and rats.
There is no toxicity information on
humans.1
Brandgefahr
Flash point data for 2-ACETAMIDOFLUORENE are not available; however, 2-ACETAMIDOFLUORENE is probably combustible.
Sicherheitsprofil
Confirmed human
carcinogen with experimental carcinogenic,
neoplas tigenic, tumorigenic, and teratogenic
data. Moderately toxic by ingestion and
intraperitoneal routes. Experimental
reproductive effects. Human mutation data
reported. When heated to decomposition it
emits toxic fumes of NOx.
m?gliche Exposition
2-AAF was intended to be used as a pesticide, but it was never marketed because this chemical was found to be carcinogenic. AAF is used frequently by biochemists and technicians engaged in the study of liver enzymes and the carcinogenicity and mutagenicity ofaromatic amines as a positive control. Therefore, these persons may be exposed to AAF.
Carcinogenicity
2-Acetylaminofluorene is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental Fate
Biological. In the presence of suspended natural populations from unpolluted aquatic systems,
the second-order microbial transformation rate constant determined in the laboratory was reported
to be 4.8 ± 2.8 x 10
-12 L/organism?h (Steen, 1991).
Chemical/Physical. Based on first-order rate constants determined at 85.5 °C, hydrolysis halflives
at pH values of 2.49, 2.97, 7.34, 9.80, 10.25, and 10.39 were 4.2, 12, 41, 13, 7.2, and 1.9 d,
respectively (Ellington et al., 1987). Releases toxic nitrogen oxides when heated to decomposition
(Sax and Lewis, 1987).
Versand/Shipping
UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.
l?uterung methode
Recrystallise it from toluene (1.3mg in 100mL). Its solubility in H2O is 1.3mg/L at 25o, UV: max nm(log ) : 288(4.43), 313(4.13). [Sawicki J Org Chem 21 271 1956.] It can also be recrystallised from 50% AcOH. [Diels et al. Chem Ber 35 3285 1902]. 9-14C and -14C 2-acetamidofluorene were recrystallised from aqueous EtOH and had m 194-195o and 194o respectively. Potent CARCINOGEN. [Miller et al. Cancer Res 9 504 1949, 10 616 1950, Sadin et al. J Am Chem Soc 74 5073 1952, Beilstein 12 H 3287, 12 IV 3373.]
Inkompatibilit?ten
Hygroscopic. Contact with strong oxidizers may cause fire and explosions. Not compatible with cyanides, acids, and/or acid anhydrides. May form unstable and explosive peroxides; a possible polymerization hazard. Contact with strong oxidizers or strong reducing agents may form flammable gases and cause fire and explosions. A weak base that may react as an acid. Incompatible with strong bases (forming potentially dangerous salts), chlorinated hydrocarbons, nitro compounds. Reacts with azo and diazo compounds, generating toxic gases. Contact with mixture of acetic acid 1 dinitrogen trioxide may cause explosion.
Waste disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Presumably high-temperature incineration with scrubber for any produced nitrogen oxides can be used
N-Fluoren-2-ylacetamid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
