PHOMOPSIN A Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.

S-S?tze Betriebsanweisung:

S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Verwenden

Phomopsin A is a an acidic 13-membered cyclic hexapeptide-like metabolite with three unusual amino acids linked in an ‘a(chǎn)nsa’ macrocycle with a tripeptide tail, terminating in a dicarboxylic acid. Phomopsin A is a potent mycotoxin produced by the fungus, Phomopsis leptostromiformis, and causes lupinosis in livestock fed infected lupins. Phomopsin A is an important bioprobe for understanding cellular structural proteins. It binds selectively to dimeric tubulin at a site overlapping that of vinblastine and maytansine, inhibiting the formation of the microtubule spindle to block cell division. Uniquely, phomopsin A protects tubulin from decay.

Enzyminhibitor

This mycotoxin and antibiotic (FW = 789.24 g/mol; CAS 64925-80-0) is obtained from Diaporthe toxica (formerly Phomopsis leptostromiformis), a fungus that grows mainly within lupin stems, the consumption of which leads to lupinosis in sheep grazing on lupin stubble. Intoxication results in liver damage, disorientation, blindness, lethargy and death in severe cases. Phomopsin A is a 13-membered ether oxygen-containing macrolide that blocks tubulin polymerization (Ki <1 μM). It also inhibits vinblastine binding to tubulin and, in common with vinblastine and maytansine, enhances colchicine binding. Phomopsin A and the depsipeptide, Dolastatin 10, bind to a site adjacent to the vinca alkaloid and nucleotide sites. This mycotoxin induces tubulin oligomerization into ring structures that cannot form microtubules. Scatchard analysis suggests two classes of binding sites: a high-affinity site (K1 = 1 x 10–8 M) and a low-affinity site (K2 = 3 x 10–7 M). Phomopsin A also inhibits rhizoxin binding, with a Ki of 0.8 x 10–8 M, suggesting that the high-affinity site of phomopsin A is identical to the rhizoxin binding site. The development and validation of an LC-MS/MS method for detecting Phomopsin A in lupin and lupincontaining retail food has been reported.

PHOMOPSIN A Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

PHOMOPSIN A Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TopScience Biochemical	00852-68527855	info@itopbiochem.com	China Hong Kong	902	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19741	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Lynnchem	86-(0)29-85992781 17792393971	info@lynnchem.com	China	4587	58
Novachemistry	44-20819178-90 02081917890	info@novachemistry.com	United Kingdom	4381	58
Shenzhen Regent Biochemical Technology Co., Ltd.	0755-0755-85201366 18938635012	sales@regentsciences.com	China	9353	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 +86-13028896684;	sales@rrkchem.com	China	57423	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58

64925-80-0()Verwandte Suche:

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• phomopsin a from phomopsis leptostromiformis
• phomopsin
• PHOMOPSIN A
• PMSA
• Phomopsin A, 98%, from Phomopsis leptostromiformis
• Aspartic acid, (βS)-3-chloro-β,5-dihydroxy-N-methyl-L-tyrosyl-3,4-didehydro-L-valyl-3-hydroxy-L-isoleucyl-3,4-didehydro-L-prolyl-(2E)-2,3-didehydroisoleucyl-2,3-didehydro-, cyclic (15→3)-ether, (2E)-
• 64925-80-0
• C36H45ClN6O12