Diphosphors?uretetrakis-(phenylmethyl)ester
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- CAS-Nr.
- 990-91-0
- Bezeichnung:
- Diphosphors?uretetrakis-(phenylmethyl)ester
- Englisch Name:
- Tetrabenzyl pyrophosphate
- Synonyma:
- PYROPHOSPHORIC ACID TETRABENZYL ESTER;TETRABENZYL DIPHOSPHATE;C2gH2gO7P2;TetrabenzyL;Bis(phenylmethox;Benzyl Pyrophosphate;Tetracyl pyrophosphate;Tetrabenzyl yrophosphate;Fosaprepitant Impurity S;Tetrabenzyl Pyrophosphte
- CBNumber:
- CB9300303
- Summenformel:
- C28H28O7P2
- Molgewicht:
- 538.47
- MOL-Datei:
- 990-91-0.mol
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Diphosphors?uretetrakis-(phenylmethyl)ester Eigenschaften
- Schmelzpunkt:
- 63-66 °C (lit.)
- Siedepunkt:
- 601.6±55.0 °C(Predicted)
- Dichte
- 1.289±0.06 g/cm3(Predicted)
- Dampfdruck
- 0.001Pa at 140℃
- storage temp.
- -20°C
- L?slichkeit
- Chloroform (Slightly), Methanol (Slightly)
- Aggregatzustand
- Powder or Crystalline Powder
- Farbe
- White to off-white
- Wasserl?slichkeit
- Slightly soluble in water.
- Sensitive
- Moisture Sensitive
- BRN
- 2068292
- InChI
- InChI=1S/C28H28O7P2/c29-36(31-21-25-13-5-1-6-14-25,32-22-26-15-7-2-8-16-26)35-37(30,33-23-27-17-9-3-10-18-27)34-24-28-19-11-4-12-20-28/h1-20H,21-24H2
- InChIKey
- NSBNXCZCLRBQTA-UHFFFAOYSA-N
- SMILES
- P(=O)(OCC1C=CC=CC=1)(OCC1C=CC=CC=1)OP(=O)(OCC1C=CC=CC=1)OCC1C=CC=CC=1
- CAS Datenbank
- 990-91-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
C |
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| R-S?tze: |
34 |
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| S-S?tze: |
26-36/37/39-45 |
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| RIDADR |
UN 3261 8/PG 2 |
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| WGK Germany |
3 |
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| F |
10-21 |
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| HazardClass |
8 |
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| PackingGroup |
II |
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| HS Code |
29209090 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H314 |
Verursacht schwere Ver?tzungen der Haut und schwere Augensch?den. |
?tzwirkung auf die Haut |
Kategorie 1B |
Achtung |
![GHS hazard pictograms]() src="/GHS05.jpg" width="20" height="20" /> |
P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501 |
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| Sicherheit |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P303+P361+P353 |
BEI BERüHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P363 |
Kontaminierte Kleidung vor erneutem Tragen waschen. |
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Diphosphors?uretetrakis-(phenylmethyl)ester Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R34:Verursacht Ver?tzungen.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Chemische Eigenschaften
White Solid
Verwenden
Tetrabenzyl pyrophosphate is used in the preparation of phosphoryl derivatives of shikimic acid in the presence of LDA. It is used in the preparation of dibenzyl phosphoro fluoridate in the presence of cesium fluoride as a catalyst. It is also used as a precursor in pharmaceuticals and involved in the phosphorylation of inositol derivatives.
synthetische
The production of tetrabenzyl pyrophosphate by the action of acyl chlorides on dibenzyl hydrogen phosphate, and a novel reaction of tetraphenyl pyrophosphate.
Preparation of Tetrabenzyl Pyrophosphate: A flask fitted with a nitrogen inlet, overhead stirrer, teflon-coated thermocouple probe, and pressure-equalizing addition funnel was charged with 350 milliliters of dry (water content ≦50 μg/mL), peroxide-free tetrahydrofuran, followed by 50.0 grams (174 millimoles) of dibenzylphosphoric acid (DBP), and the resulting mixture was stirred until the solid dissolved (about 10-15 minutes). A solution of 18.9 grams (91.6 millimoles) of dicyclohexylcarbodiimide (DCC) in 215 milliliters of THF was added from the addition funnel to a stirred, cooled (water-bath) solution of DBP at a rate to maintain the temperature at about 20°-25° C. The reaction is slightly exothermic and the addition took about 30 minutes. Within minutes, a precipitate of dicyclohexylurea formed in the mixture. Stirring was continued for about 2 hours at 20°-25° C. The reaction was monitored by HPLC assay using VYDAC C-18 (300A, 4.6×250 mm) column with water (0.02M KH2PO4) acetonitrile as eluent. The reaction was complete in about 1 hour (assay showing <2 percent unreacted DBP). The mixture was then filtered while excluding moisture to remove dicyclohexylurea. The filter cake was washed with two 25 milliliter portions of THF. The solution when assayed by HPLC showed 45.9 grams (98 percent) yield of tetrabenzyl pyrophosphate (TBPP) in 620 milliliters of THF (0.137M). The filtrate was then stored at 0° C. with exclusion of moisture until the next step.
Diphosphors?uretetrakis-(phenylmethyl)ester Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Diphosphors?uretetrakis-(phenylmethyl)ester Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 311)Lieferanten
990-91-0(Diphosphors?uretetrakis-(phenylmethyl)ester)Verwandte Suche:
- TETRABENZYL PYROPHOSPHATE
- Tetrabenzyl pyrophosphate, tech.
- Pyrophosphoric acid tetrabenzyl ester, Tetrabenzyl diphosphate
- Bis(phenylmethoxy)phosphoryl bis(phenylmethyl) phosphate
- Benzyl Pyrophosphate
- Diphosphoric Acid P,P,P',P'-Tetrakis(phenylMethyl) Ester
- Tetrabenzyl yrophosphate
- Tetrabenzyl pyrophosphate Pyrophosphoric acid tetrabenzyl ester
- Tetrabenzyl pyrophosphate 98%
- dibenzyl {[bis(benzyloxy)phosphoryl]oxy}phosphonate
- Bis(phenylmethox
- yrophosphoric acid tetrabenzyl ester
- TetrabenzylPyrophosphate>
- Tetrabenzyl pyrophosphate, 99%, for synthesis
- TetrabenzyL
- Tetrabenzylpyrophosphate (TBPP)
- TETRABENZYL PYROPHOSPHATE 990-91-0
- Creatine Phosphate Impurity 21（Tetrabenzyl Diphosphate）
- Fosaprepitant Impurity S
- Tetrabenzyl
Pyrpophosphate
- dibenzyl bis(phenylmethoxy)phosphoryl phosphate
- PYROPHOSPHORIC ACID TETRABENZYL ESTER
- TETRABENZYL DIPHOSPHATE
- Tetracyl pyrophosphate
- P,P,P',P'-Tetrakis(phenylmethyl) (diphosphate)
- Tetrabenzyl Pyrophosphte
- C2gH2gO7P2
- 990-91-0
- C28H28O7P2
- C6H5CH2O2POOPOOCH2C6H52
- Building Blocks
- Organic Phosphates/Phosphites
- Phosphorus Compounds
- Organic Building Blocks
- DNA / RNA Synthesis
- Phosphorylation
- Phosphorylating Agents
- Phosphorylating and Phosphitylating Agents
- Biochemistry
- Nucleosides, Nucleotides & Related Reagents
- Phosphorylating and Phosphorothioating Agents
- Phosphorylation
- Protecting Agents, Phosphorylating Agents & Condensing Agents
- Synthetic Organic Chemistry
