Anti-bGLU-Lp Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-Gapex-5 antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.
Allgemeine Beschreibung
GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1) also called Rab5-activating protein 6 (RAP6) or Gapex-5 gene is mapped to the human chromosome 9q33.3. It has a carboxy-terminal Vps9-like domain and an amino-terminal Ras GTPase-accelerating proteins (GAP)-like domain. GAPVD1 is present in the plasma membrane and endosomes.
Biochem/physiol Actions
GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.
Anti-bGLU-Lp Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
