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Anti-Prostate differentiation factor

Anti-Prostate differentiation factor Struktur
CAS-Nr.
Englisch Name:
Anti-Prostate differentiation factor
Synonyma:
MIC1;GDF-15;HsT2591;C18orf8;Anti-PDF;FLJ23453;Anti-PLAB;Anti-NRG-1;Anti-NAG-1;Anti-MIC-1
CBNumber:
CB92879564
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

Anti-Prostate differentiation factor Eigenschaften

storage temp. 
-20°C
Aggregatzustand
buffered aqueous solution

Sicherheit

Anti-Prostate differentiation factor Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit .

Allgemeine Beschreibung

GDF15 (growth differentiation factor 15) is a part of the transforming growth factor-β (TGFβ) or bone morphogenetic protein (BMP) superfamily. This gene resides in human chromosomal locus 19p12.1-13.1, and contains two exons. The pro-protein is a dimer containing a disulfide linkage which undergoes cleavage at RXXR sequence, by furin-like protease. The mature protein is a C-terminal dimer composed of 112 amino acids.

Biochem/physiol Actions

GDF15 (growth differentiation factor 15) is released in response to stress such as, inflammation, oxidative stress and hypoxia, from multiple tissues, such as heart and liver. Studies show that it is responsible for the down-regulation of microRNAs of muscles, leading to intensive care unit-acquired weakness (ICUAW) and related muscle atrophy. It also controls the developmental processes underlying embryogenesis, osteogenesis, and hematopoiesis. It also regulates adipose tissue function, cartilage and bone synthesis and immune response. It is involved in tissue injury and repair processes. It is up-regulated in melanoma, thyroid, breast, pancreatic, gastrointestinal, prostate and colorectal cancer. It is involved in tumorigenesis, and abnormal expression is related to poor prognosis in various cancers. It is a biomarker for multiple epithelial cancers such as, renal cell carcinoma, adenocarcinoma of the esophagus, ovary and colon. In glioblastomas, it acts as a tumor suppressor gene and induces apoptosis.

Anti-Prostate differentiation factor Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Anti-Prostate differentiation factor Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 37)Lieferanten
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Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51456 80
DC Chemicals 021-58447131 13564518121
sales@dcchemicals.com China 9409 58
Wuhan Chemstan Biotechnology Co., Ltd. 027-65317797 15926423062
422450190@qq.com China 10424 58
Shanghai Huzhen Industrial Co., LTD 021-60345367 13916550749
sales@shzbio.com China 9966 58
Biolab Reagents 027-65279366 18108604862
products@biolabreagent.com China 9818 58
Beijing Boorsen Biotechnology Co., Ltd 400-901-9800 18611424007
cis@bioss.com.cn China 9518 58
ACROBiosystems 18514007688
jiaxin.zhao@acrobiosystems.com China 1183 58
United States Biological --
sales@advtechind.com United States 6075 58

  • Anti-GDF15 antibody produced in rabbit
  • Anti-Growth/differentiation factor 15 precursor
  • Anti-Macrophage inhibitory cytokine 1
  • Anti-MIC-1
  • Anti-NAG-1
  • Anti-NRG-1
  • Anti-NSAID-regulated protein 1
  • Anti-Placental bone morphogenetic protein
  • Anti-Placental TGF-β
  • Anti-Prostate differentiation factor
  • Anti-GDF15 antibody produced in goat
  • Anti-PLAB
  • Anti-nonsteroidal anti-inflammatory drug-activated gene
  • Anti-NSAID-activated gene 1 protein
  • Monoclonal Anti-NAG-1 antibody produced in mouse
  • GDF-15
  • Growth/differentiation factor 15
  • Macrophage inhibitory cytokine 1
  • Placental bone morphogenetic protein
  • Placental TGF-β
  • Anti-PTGFB
  • Monoclonal Anti-GDF15 antibody produced in mouse
  • Anti-GDF-15
  • Anti-GDF15, (N-terminal) antibody produced in rabbit
  • Anti-PDF
  • Macrophage inhibitory cyotkine-1
  • Monoclonal Anti-p13 antibody produced in mouse
  • Anti-C18orf8 antibody produced in goat
  • chromosome 18 open reading frame 8
  • FLJ23453
  • HsT2591
  • C18orf8
  • Colon cancer-associated protein Mic1
  • MIC1
  • Uncharacterized protein C18orf8
  • Anti-C18ORF8 antibody produced in rabbit
  • Anti-chromosome 18 open reading frame 8
  • Anti-HsT2591
  • Anti-C18orf8
  • Anti-Colon cancer-associated protein Mic1
  • Anti-MIC1 (center) antibody produced in rabbit
  • Anti-Uncharacterized protein C18orf8
  • ANTI-MIC1(N-TERMINAL) antibody produced in rabbit
  • growth differentiation factot15
  • Recombinant Mouse Gdf15 Protein, His Tag
  • Human GDF15 Protein, Fc Tag
  • Human GDF15 Protein, His Tag
  • Rabbit Anti-GDF15 antibody
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