2,5-DiMethyl Celecoxib
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- CAS-Nr.
- 457639-26-8
- Englisch Name:
- 2,5-DiMethyl Celecoxib
- Synonyma:
- Celecoxib-13;5-dimethyl Celecoxib;Celecoxib Impurity K;Celecoxib impurity T;Celecoxib Impurity 42;Celecoxib 2,5-Dimethyl;2,5-DiMethyl Celecoxib;2,5-DiMethyl-celecoxib DMC;2,5dimethyl Celecoxib,2,5 dimethyl Celecoxib;4-[5-(2,5-Dimethyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide
- CBNumber:
- CB92543122
- Summenformel:
- C18H16F3N3O2S
- Molgewicht:
- 395.4
- MOL-Datei:
- 457639-26-8.mol
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2,5-DiMethyl Celecoxib Eigenschaften
- Schmelzpunkt:
- >138°C (dec.)
- Siedepunkt:
- 516.7±60.0 °C(Predicted)
- Dichte
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- room temp
- L?slichkeit
- DMSO: soluble20mg/mL, clear
- pka
- 9.67±0.10(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
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| R-S?tze: |
25 |
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| S-S?tze: |
45 |
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| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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2,5-DiMethyl Celecoxib Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
A non-cyclooxygenase-2 inhibitor analog of Celecoxib (C251000). The celecoxib analog, 2,5-di-Me celecoxib (DMC), lacks COX-2 inhibitory activity but exhibits cytotoxic properties comparable to the COX-2 inhibitor Celecoxib.
Biochem/physiol Actions
Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.
2,5-DiMethyl Celecoxib Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2,5-DiMethyl Celecoxib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 70)Lieferanten
- 4-[5-(2,5-DiMethylphenyl)-3-(trifluoroMethyl)-1H-pyrazol-1-yl]benzenesulfonaMide
- 2,5-DiMethyl-celecoxib DMC
- 2,5-Dimethylcelecoxib 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide
- 2,5-DiMethyl Celecoxib
- 4-[5-(2,5-Dimethyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide
- Celecoxib-13
- Celecoxib Impurity 42
- Celecoxib Impurity K
- Celecoxib 2,5-Dimethyl
- Benzenesulfonamide, 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-
- 5-dimethyl Celecoxib
- Celecoxib impurity T
- 2,5dimethyl Celecoxib,2,5 dimethyl Celecoxib
- 457639-26-8
- Amines
- Aromatics
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
