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2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Struktur
265312-55-8
CAS-Nr.
265312-55-8
Englisch Name:
2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
Synonyma:
RYUVIDINE;Cdk4 Inhibitor III;2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione;2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE;2-methyl-5-[(4-methylphenyl)amino]benzothiazole-4,7-dione;4,7-Benzothiazoledione, 2-methyl-5-[(4-methylphenyl)amino]-
CBNumber:
CB92453429
Summenformel:
C15H12N2O2S
Molgewicht:
284.33
MOL-Datei:
265312-55-8.mol

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Eigenschaften

Siedepunkt:
463.8±45.0 °C(Predicted)
Dichte
1.416±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
L?slichkeit
Soluble to 20 mM in DMSO and to 5 mM in ethanol
Aggregatzustand
Black-purple solid
pka
-1.63±0.20(Predicted)
Farbe
Brown to black

Sicherheit

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Ryuvidine is an antifungal agent used against pathogenic fungi.

Allgemeine Beschreibung

A cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 μM for Cdk4/D1 and >200 μM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 μg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).

Biologische Aktivit?t

Cyclin-dependent kinase (cdk) 4 inhibitor (IC 50 = 6.0 μ M at cdk4/cyclin D1) that displays > 33-fold selectivity over cdk2 (IC 50 > 200 μ M at cdk2/cyclin A). Cytotoxic against a range of human cancer cells (IC 50 values are 0.30, 0.61, 1.08 and 1.21 μ g/mL for HL-60, A549, Col 1 and HepG2 cells respectively).

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 46)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715
 admin@nexconn.com China 10311 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Tianjin shanhaijing medicine technology co., ltd 19129375004 15321929114
 yangtzechem@163.com China 514 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4575 55
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8447 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58
Shanghai Changyan Chem & Tech Co., Ltd. 021-20242659 18930833303
 Sales@changyanchem.cn China 5010 55
DC Chemicals 021-58447131 13564518121
 sales@dcchemicals.com China 9409 58
  • 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
  • RYUVIDINE
  • Cdk4 Inhibitor III
  • 2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione
  • 4,7-Benzothiazoledione, 2-methyl-5-[(4-methylphenyl)amino]-
  • 2-methyl-5-[(4-methylphenyl)amino]benzothiazole-4,7-dione
  • 265312-55-8
  • C15H13N2O2S
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