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FURIN

FURIN Struktur
141760-45-4
CAS-Nr.
141760-45-4
Englisch Name:
FURIN
Synonyma:
FURIN;Furin human
CBNumber:
CB9159015
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

FURIN Eigenschaften

storage temp. 
-20°C
Aggregatzustand
buffered aqueous solution

Sicherheit

S-S?tze: 23-24/25
WGK Germany  1

FURIN Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S24/25:Berührung mit den Augen und der Haut vermeiden.

Verwenden

Furin is capable of cleaving precursors of a wide variety of proteins, including growth factors, serum proteins, including proteases of the blood-clotting and complement systems, matrix metalloproteinases, receptors, viral-envelope glycoproteins, and bacterial exotoxins, typically at sites marked by the consensus sequence Arg-Xaa-(Lys/Arg)-Arg.

Allgemeine Beschreibung

Furin also known as paired basic Amino acid Cleaving Enzyme (PACE), is an enzyme which belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. Furin is enriched in the Golgi apparatus, where it functions to cleave other proteins into their mature/active forms. The expression of furin in T-cells is required for maintenance of peripheral immune tolerance. Furin cleaves proteins just downstream of a basic amino acid target sequence (canonically, Arg-X-(Arg/Lys) -Arg′). PACE is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. In addition to processing cellular precursor proteins, furin is also utilized by a number of pathogens. For example, the envelope proteins of viruses such as HIV, influenza and dengue fever viruses must be cleaved by furin or furin-like proteases to become fully functional. PACE also play a role in tumor progression.

Biochem/physiol Actions

Furin is a dibasic endoprotease that is localized in the Golgi apparatus. It has a molecular mass of 52.7 kDa. It is responsible for the proteolytic maturation of many precursor proteins in the secretory and endocytic pathways of mammalian cells. Furin cleaves precursor proteins at their paired basic amino acid processing sites. Some substrates of furin include von Willebrand factor, transforming growth factor beta 1 precursor, pro-beta-secretase and proparathyroid hormone.

FURIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


FURIN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 26)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Creative Enzymes
1-516-855-7709
info@creative-enzymes.com United States 8748 58
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969
isunpharm@qq.com China 4674 55
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51456 80
Guangzhou Tomums Life Science Co., Ltd. 020-31155029 18902330969
sales@tomums.cn China 4696 58
Shanghai Huzhen Industrial Co., LTD 021-60345367 13916550749
sales@shzbio.com China 9966 58
Biolab Reagents 027-65279366 18108604862
products@biolabreagent.com China 9818 58
ACROBiosystems 18514007688
jiaxin.zhao@acrobiosystems.com China 1183 58

  • Furin human
  • FURIN
  • 141760-45-4
  • Enzymes, Inhibitors, and Substrates
  • Proteolytic Enzymes
  • Proteolytic Enzymes and Substrates
  • Biochemicals and Reagents
  • BioChemical
  • FurinEnzymes, Inhibitors, and Substrates
  • 3.4.x.x Peptidases
  • 3.x.x.x Hydrolases
  • Proteolytic Enzymes and Substrates
  • Proteolytic EnzymesEnzyme Class Index
  • Selective Proteolytic Enzymes
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