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gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1)

Chlorphenamine maleate Struktur
113-92-8
CAS-Nr.
113-92-8
Bezeichnung:
gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1)
Englisch Name:
Chlorphenamine maleate
Synonyma:
chlorphenamine;CHLORTRIMETON;CHLOROPHENIRAMINE MALEATE;CHLORPHENIRAMINE BASE;Puermin;piriton;teldrin;Histadur;antagonate;Chlorpheniramine maleat
CBNumber:
CB9142008
Summenformel:
C20H23ClN2O4
Molgewicht:
390.86
MOL-Datei:
113-92-8.mol

gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1) Eigenschaften

Schmelzpunkt:
130-135 °C (lit.)
alpha 
-1~+1°(D/20℃)(c=5,DMF)
Dichte
1.1984 (rough estimate)
Brechungsindex
1.6800 (estimate)
Flammpunkt:
9℃
storage temp. 
2-8°C
L?slichkeit
Freely soluble in water, soluble in ethanol (96 per cent)
Aggregatzustand
Solid
Farbe
White to Almost white
Geruch (Odor)
odorless
PH
4.0~5.5 (10g/l, 25℃)
Wasserl?slichkeit
1-5 g/100 mL at 21 ºC
Merck 
14,2180
BCS Class
3/1
InChIKey
DBAKFASWICGISY-BTJKTKAUSA-N
LogP
3.389 (est)
EPA chemische Informationen
Chlorpheniramine maleate (113-92-8)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T,F
R-S?tze: 25-39/23/24/25-23/24/25-11
S-S?tze: 36/37/39-45-36/37-16
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS-Nr. US6504000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29333990
Toxizit?t LD50 orally in mice: 162 mg/kg (Smith)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit

gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1) Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R25:Giftig beim Verschlucken.

S-S?tze Betriebsanweisung:

S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Chlorpheniramine is a histamine H1 receptor antagonist with an IC75 value of 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum. It protects against intravenous histamine-induced death (PD50 = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED100sec = 0.44 mg/kg) in guinea pigs. Chlorpheniramine (20 mg/kg, i.p.) prevents histamine-induced passive cutaneous anaphylaxis (PCA) in rabbits. It also reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma. Formulations containing chlorpheniramine have been used in the treatment of seasonal allergies.

Chemische Eigenschaften

White Solid

Verwenden

(±)-Chlorpheniramine maleate salt has been used:
  • as H1 receptor antagonist to determine the receptor function
  • to block the effect of compound 48/80 on plasma IGF-I
  • as a standard for fast sensing and determination by sequential injector coupled with potentiometer

Allgemeine Beschreibung

Odorless white crystalline solid or white powder with a bitter taste. pH (2% aqueous solution) 5. pH (1% aqueous solution) 4-5.

Air & Water Reaktionen

Water soluble.

Reaktivit?t anzeigen

A halogenated amine, ester. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Brandgefahr

Flash point data for Chlorpheniramine maleate are not available; however, Chlorpheniramine maleate is probably combustible.

Sicherheitsprofil

Poison by ingestion, intravenous, and subcutaneous routes. Experimental reproductive effects. Used as an antihistamine. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx.

gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 795)Lieferanten
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Hebei Chuanghai Biotechnology Co., Ltd
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Shaanxi Dideu Medichem Co. Ltd
+86-29-81139210 +86-18192627656
1059@dideu.com China 3177 58
Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850 +86-13986145403;
info@fortunachem.com China 5919 58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
+86-029-86333380 +86-18829239519
sales06@tgybio.com China 898 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
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sales@sdperfect.com China 294 58
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+86-0533-2185556 +8615965530500
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+86-371-86557731 +86-13613820652
info@fdachem.com China 20205 58
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+undefined15081010295
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113-92-8(gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1))Verwandte Suche:


  • 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethy-laminopropanebimaleate
  • 1-Parachlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate
  • 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)
  • Chlorophenamine
  • Chlorprophenpyridamine maleate
  • Cloropiril
  • Histaspan
  • Pyridine, 2-[p-chloro-α-[2-(dimethylamino)ethyl]benzyl]-, maleate (1:1) (8CI)
  • (+-)-Chloropheniramine
  • 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
  • 2-[p-Chloro-α-[2-(dimethylamino)ethyl]benzyl]pyridine
  • 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-
  • 3-(p-Chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine
  • 4-Chloropheniramine
  • 9: PN: US20030109453 SEQID: 8 claimed sequence
  • Allergican
  • Chlorophenylpyridamine
  • Chloroprophenpyridamine
  • Chlorprophenpyridamine
  • dl-1-(p-Chlorophenyl)-1-(2-pyridyl)-3-(dimethylamino)propane
  • Haynon
  • RS-Chlorpheniramine
  • γ-(4-Chlorophenyl)-γ-(2-pyridyl)propyldimethylamine
  • 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridin maleate
  • 1-(p-chlorophenyl)-1-(2-pyridyl)-3-n,n-dimethylpropylamine
  • 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridin
  • 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine
  • 2-[p-chloro-alpha-(2-dimethylaminoethyl)benzyl]pyridine
  • gamma-(4-chlorophenyl)-n,n-dimethyl-2-pyridinepropanamin
  • CHLOROPHENIRAMINE BASE
  • Chlorpheniramine (base and/or unspecified salts)
  • 1-(N,N-Dimethylamino)-3-(p-chlorophenyl)-3-(alpha-pyridyl)propane maleate
  • 1-p-Chlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate
  • Chlorphenamine hydrogen maleate
  • 1-(p-chlorphenyl)-1-(2-pyridyl)-3-dimethylaminopropanmaleat
  • 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridinmaleate(1:1)
  • allerclor
  • allergin
  • alunex
  • carbinoxamidemaleate
  • chlormene
  • chloroprophenpyridaminemaleate
  • chlor-tripolon
  • c-meton
  • dl-2-(p-chloro-alpha-2-(dimethylamino)ethylbenzyl)pyridinemaleate
  • gamma-(4-chlorophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-2-butenedioa
  • gamma-(4-chlorophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-2-butenedioate
  • histadurdura-tabs
  • ibioton
  • lorphen
  • m.p.chlorcapst.d.
  • nci-c55265
  • neorestamin
  • piriex
  • polaronil
  • pyridamal-100
  • synistamin
  • LABOTEST-BB LT00134667
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