SU 6668 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

PDGFR Tyrosine Kinase Inhibitor VI, SU6668 is a potent ATP-competitive inhibitor against tyrosine kinases.

Allgemeine Beschreibung

A cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC₅₀ = 0.01, 0.1, 3.9, and 3.8 μM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development in vivo. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC₅₀ = 0.85, 0.047, 1.4, and 1.8 μM, respectively), as well as non-receptor TKs Lyn and Yes (IC₅₀ = 4.3 and 5.8 μM, respectively).

SU 6668 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

SU 6668 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	dominicguo@gk-bio.com	CHINA	9414	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Shaoxin Catsyn Co., Ltd.	+undefined-0575-82040869 +86-0575-82040869;	sales@catsyn.com	China	6114	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2922	55
Nanjing Chemlin Chemical Co., Ltd	025-83697070	info@chemlin.com.cn	China	19179	64
Nanjing JinruiJiuAn Biotechnology Co., Ltd.	025-58196018 800028039	sales@fartop.net	China	2229	55
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
SPIRO PHARMA		eric_feng1954@126.com	China	9248	55

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• SU 6668
• 3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)-propionic acid
• 1H-Pyrrole-3-propanoic acid, 5-((Z)-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-
• 5-((Z)-1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-propanoic acid
• PDGFR Tyrosine Kinase Inhibitor VI, SU6668
• 3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoicacid
• PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem
• 3-(2,4-Dimethyl-5-{[(3Z)-2-oxo-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid
• (Z)?-?3-?(2,?4-?Dimethyl-?5-?((2-?oxoindolin-?3-?ylidene)?methyl)?-?1H-?pyrrol-?3-?yl)?propanoic acid (SU-6668)
• (Z)-Orantinib
• (Z)-SU6668
• (Z)-TSU-68
• 5-(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl-2,4-dimethyl-1H-pyrrol-3-propanoic acid
• (Z)-Orantinib/SU6668/TSU-68)
• 210644-62-5