2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
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- CAS-Nr.
- 114289-47-3
- Englisch Name:
- 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
- Synonyma:
- CI 976;PD 128042;CI-976
(PD 128042);N-(2,4,6-Trimethoxyphenyl)-2,2-dimethyldodecanamide;2,2-DIMETHYL-N-(2,4,6-TRIMETHOXYPHENYL)DODECANAMIDE;2,2-dimethyl-n-(2,4,6-trimethoxyphenyl)-dodecanamid;Dodecanamide, 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-;inhibit,oral,PD128042,PD 128042,CI-976,Diacylglycerol acyltransferase,PD-128042,Acyltransferase,transferase,secretory,LPAT,acyl-CoA:cholesterol acyltransferase,mono- acylglycerol acyltransferase,endocytic membrane trafficking pathway,ACAT,CI976,Diglyceride acyltransferase,Inhibitor
- CBNumber:
- CB9130672
- Summenformel:
- C23H39NO4
- Molgewicht:
- 393.56
- MOL-Datei:
- 114289-47-3.mol
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2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Eigenschaften
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: >10mg/mL
- Aggregatzustand
- solid
- Farbe
- White to off-white
- InChI
- InChI=1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25)
- InChIKey
- WAFNZAURAWBNDZ-UHFFFAOYSA-N
- SMILES
- C(NC1=C(OC)C=C(OC)C=C1OC)(=O)C(C)(C)CCCCCCCCCC
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
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Sicherheit |
P261 |
Einatmen von Staub vermeiden. |
P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT-1) is a sterol
O-acyltransferase that catalyzes the formation of fatty acid-cholesterol esters, an important step in lipoprotein assembly and dietary cholesterol absorption. CI-976 is a potent, selective inhibitor of ACAT-1 (IC
50 = 73 nM). It is orally bioavailable and decreases plasma total cholesterol, very low density lipoprotein (VLDL) cholesterol, LDL cholesterol, apolipoprotein B, liver cholesteryl esters, and VLDL and LDL cholesteryl ester content in rabbits given a diet that induces hypercholesterolemia. CI-976 also diminishes atherosclerotic activity in hypercholesterolemic rabbits.
Verwenden
CI-976 (2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide) is a selective inhibitor of Acyl-coenzyme A: cholesterol Acyltransferase 1 (ACAT-1), a sterol O-acetyltransferase that catalyzes information of fatty acid-cholesterol esters. Orally bioavailable and decreses plasma total cholesterol
Biologische Aktivit?t
Selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC 50 = 0.073 μ M). Lowers non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol concentrations in rats with pre-established dyslipidaemia. Orally active.
2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 73)Lieferanten
114289-47-3()Verwandte Suche:
- 2,2-dimethyl-n-(2,4,6-trimethoxyphenyl)-dodecanamid
- 2,2-DIMETHYL-N-(2,4,6-TRIMETHOXYPHENYL)DODECANAMIDE
- CI 976
- PD 128042
- N-(2,4,6-Trimethoxyphenyl)-2,2-dimethyldodecanamide
- CI-976
(PD 128042)
- Dodecanamide, 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-
- inhibit,oral,PD128042,PD 128042,CI-976,Diacylglycerol acyltransferase,PD-128042,Acyltransferase,transferase,secretory,LPAT,acyl-CoA:cholesterol acyltransferase,mono- acylglycerol acyltransferase,endocytic membrane trafficking pathway,ACAT,CI976,Diglyceride acyltransferase,Inhibitor
- 114289-47-3
- Miscellaneous Compounds
- Selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor.