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Integrase Inhibitors

Integrase Inhibitors Struktur
CAS-Nr.
Englisch Name:
Integrase Inhibitors
Synonyma:
Integrase Inhibitors
CBNumber:
CB91306269
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

Integrase Inhibitors Eigenschaften

Sicherheit

Integrase Inhibitors Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

Two closely related types of small molecules that blockstrand transfer catalyzed by recombinant integrase havebeen identified. Both types show in vitro antiviral activity.The diketo acids1 inhibit strand transfer catalyzed by recombinantintegrase with an IC50 less than 0.1μm.Mutations that conferred resistance to the diketo acidsmapped near conserved residues in the IN enzyme. Thisfinding demonstrates that the compounds have a highlyspecific mechanism of action. X-ray crystallography of thebound tetrazole derivative revealed that the inhibitorwas centered in the active site of IN near acidic catalyticresidues.

Integrase Inhibitors Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


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