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Halofuginone hydrobromide

Halofuginone hydrobromide Struktur
64924-67-0
CAS-Nr.
64924-67-0
Englisch Name:
Halofuginone hydrobromide
Synonyma:
STENOROL;Ru-19110;Tempostatin;RU-19110(HBr);CID 121225393;Unii-ptc2969mv1;55837-20-2 (free);RU-19110 (hydrobromide);HALOFUGINONEHYDROBROMIDE;Haloperidone hydrobromide
CBNumber:
CB91230111
Summenformel:
C16H17BrClN3O3.HBr
Molgewicht:
495.59
MOL-Datei:
64924-67-0.mol

Halofuginone hydrobromide Eigenschaften

Schmelzpunkt:
247° (dec)
storage temp. 
Store at -20°C
L?slichkeit
Soluble to 100 mM in DMSO.
Aggregatzustand
Solid
Farbe
White to off-white
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
RIDADR  UN2811 - class 6.1 - PG 1 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany  3
RTECS-Nr. VA2397066
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H410 Sehr giftig für Wasserorganismen mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 1 Warnung GHS hazard pictogramssrc="/GHS09.jpg" width="20" height="20" /> P273, P391, P501
Sicherheit
P262 Nicht in die Augen, auf die Haut oder auf die Kleidung gelangen lassen.
P273 Freisetzung in die Umwelt vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Halofuginone hydrobromide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Halofuginone hydrobromide (Halofuginone) is a specific collagen Type I inhibitor that antagonize or inhibit the development of new blood vessels, hence can prevent intimal hyperplasia at a vascular anastomosis. It is used in the treatment or prevention of coccidiosis in both humans and animals.

Chemische Eigenschaften

White to Off-White Solid

Verwenden

Halogenated derivative of Febrifugine. Halofuginone hydrobromide is used as an antiprotozoal (coccidiostat).

Definition

The hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases.

Biologische Aktivit?t

Halofuginone hydrobromide is a high affinity competitive prolyl-tRNA synthetase inhibitor (Ki = 18.3 nM). Blocks expression of MMP2. Inhibits ECM invasion in vitro and lung metastasis by bladder cancer cells in mice. Inhibits the development of Th17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway. Also antiparasitic.

Toxikologie

Halofuginone HBr (Halofuginone hydrobromide) is toxic by inhalation, dermal and ocular routes and is very irritant to both the eye and the skin. It is considered also a skin sensitiser[1].

Halofuginone hydrobromide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Halofuginone hydrobromide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 131)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131957 58
Enki Biopharmaceuticals (Shanghai) Limited
+86-0086-2157680326 +8613916707528
yusu@enkibiopharma.com China 48 58
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897
sales@biopurify.com China 3772 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5906 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30239 58
Aktin Chemicals, Inc.
028-85159085
info@aktinchem.com CHINA 1025 58

64924-67-0()Verwandte Suche:


  • Ru-19110
  • Tempostatin
  • Unii-ptc2969mv1
  • rel-7-BroMo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone HydrobroMide
  • trans-(+/-)-7-BroMo-6-chloro-3-[3-(3-hydroxy-2- piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone MonohydrobroMide
  • 7-BroMo-6-chloro-3-(3-((2S,3R)-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one hydrobroMide
  • HALOFUGINONEHYDROBROMIDE
  • STENOROL
  • 7-Bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one hydrobromide
  • 4(3H)-Quinazolinone,7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-,hydrobromide (1:1), rel-
  • (+/-)-trans-7-Bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone monohydrobromide
  • 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(2R,3S)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-, monohydrobromide, rel-
  • 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrobromide, trans-(+-)-
  • 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrobromide, trans-(+/-)-
  • Trans-halofuginone hydrobromide
  • HALOFUGINONE HBR ((2R,3S) AND (2S,3R) MIXTURE)
  • 55837-20-2 (free)
  • Halofuginone Hydrobromide 64924-67-0
  • (2R*,3S*)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide
  • RU-19110(HBr)
  • RU-19110 (hydrobromide)
  • 7-Bromo-6-chloro-3-(3-((2S,3R)-rel-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one hydrobromide
  • Haloperidone hydrobromide
  • (3R,4R)-4-(2,5-Difluoro-phenyl)-3-methyl-4-[1,2,4]triazol-1-ylmethyl-oxetan-2-one
  • Halofuginone hydrobromide 100 μg/ml Acetonitrile
  • CID 121225393
  • 64924-67-0
  • C16H18Br2ClN3O3
  • Amines
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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