N-Hydroxynorborn-5-en-2,3-dicarboximid
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- CAS-Nr.
- 21715-90-2
- Bezeichnung:
- N-Hydroxynorborn-5-en-2,3-dicarboximid
- Englisch Name:
- N-Hydroxy-5-norbornene-2,3-dicarboximide
- Synonyma:
- HONB;N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIC ACID IMIDE;2-Hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione;N-Hydroxy-5-norborne;LABOTEST-BB LT00112336;Endo-N-Hydroxy-5-Norbornene-2,;N-Hydroxynorborna-5-ene-2,3-dicarbimide;N-Hydroxy-5-Norborene-2,3-Dicarboximide;N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE;N-hydroxynorborn-5-ene-2,3-dicarboximide
- CBNumber:
- CB9121858
- Summenformel:
- C9H9NO3
- Molgewicht:
- 179.17
- MOL-Datei:
- 21715-90-2.mol
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N-Hydroxynorborn-5-en-2,3-dicarboximid Eigenschaften
N-Hydroxynorborn-5-en-2,3-dicarboximid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
N-Hydroxy-5-norbornene-2,3-dicarboximide (NHD) is a compound that has
antiviral activity and is used to treat HIV infections. It inhibits the
reverse transcriptase enzyme in the virus, which blocks the synthesis of
viral DNA. The ferroelectric properties of NHD were first observed by
observing changes in its melting point when mixed with water. This
property makes it useful for diagnosis purposes. In animal studies, a
dose of 5 mg/kg was found to be effective against cancer cells and the
drug showed no toxicity in humans at doses up to 500 mg/day. The optimal
reaction conditions for NHD are pH 6 and temperature 45 degrees
Celsius.
Chemische Eigenschaften
white to off-white crystalline powder
Verwenden
N-Hydroxy-5-norbornene-2,3-dicarboximide(HONB) is used in solution-phase peptide synthesis. Used in the synthesis of enkephalin analogs.
l?uterung methode
Dissolve the imide in CHCl3, filter, evaporate and recrystallise from EtOAc. IR (nujol): max 1695, 1710 and 1770 (C=O), and 3100 (OH) cm-1. The O-acetyl derivative has m 113-114o (from EtOH) with IR bands at max 1730, 1770 and 1815 cm-1 only, and the O-benzoyl derivative has m 143-144o (from propan-2-ol or *C6H6). [Bauer & Miarka J Org Chem 24 1293 1959, Fujino et al. Chem Pharm Bull Jpn 22 1857 1974]. [Beilstein 21/10 V 188.]
N-Hydroxynorborn-5-en-2,3-dicarboximid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
N-Hydroxynorborn-5-en-2,3-dicarboximid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 277)Lieferanten
21715-90-2(N-Hydroxynorborn-5-en-2,3-dicarboximid)Verwandte Suche:
1,1'-(Methylendi-p-phenylen)bismaleimid
Phthalimid
N-Chlorsuccinimid
3,6-Bis[(4-chlor-2-phosphonophenyl)azo]-4,5-dihydroxynaphthalin-2,7-disulfonsure
Dispersing agent 155
Succinimid
Polyamideimide
Dialifos (ISO)
8,9,10-Trinorborn-2-en
8,9,10-Trinorborn-5-en-2,3-dicarbonsure
exo-Bicyclo[2.2.1]heptan-2-ol
3a,4,7,7a-Tetrahydro-1,3(2H)-dioxo-4,7-methano-1H-isoindol-2-yl-(benzyloxy)formiat
N-Hydroxynorborn-5-en-2,3-dicarboximid
- N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIMIDE
- N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE
- N-HYDROXYBICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLIC ACID IMIDE
- N-HYDROXYBICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXIMIDE
- LABOTEST-BB LT00112336
- 3(2h)-dione,3a,4,7,7a-tetrahydro-2-hydroxy-7-methano-1h-isoindole-1
- HONB, N-Hydroxybicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid imide
- 3a,4,7,7a-Tetrahydro-2-hydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione
- 4-Hydroxy-4-azatricyclo[5.2.1.02,6]deca-8-ene-3,5-dione
- N-Hydroxybicyclo[2.2.1]hepta-5-ene-2,3-dicarbimide
- N-Hydroxynorborna-5-ene-2,3-dicarbimide
- N-Hydroxybicyclo[2.2.1]-5-heptene-2,3-dicarboxiMide
- N-Hydroxy-5-norborne
- N-Hydroxy-5-norbornene-endo-2,3-dicarboximide97%
- N-Hydroxy-5-norbornene-2,3-dicarboxylic acid imide 97%
- N-Hydroxy-5-norbornene-2.3-dicarboxylic imide
- endo-N-Hydroxybicyclo[2.2.1]hept-5-ene-2,3-dicarbo
- Honb(N-Hydrozy-5-Norbornene-2.3-DicarboxylicImide)
- N-Hydroxy-5-Norborene-2,3-Dicarboximide
- N-Hydroxy-5-norbornene-2,3-dicarboximide, 99+%
- Endo-N-Hydroxy-5-Norbornene-2,
- HONB N-Hydroxy-5-norbornene-endo-2,3-dicarboximide N-Hydroxybicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid imide
- HONB, endo-N-Hydroxy-5-norbornene-2,3-dicarboximide
- ENDO-N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE HONB
- HONB N-HYDROXY-5-NORBORNENE-2.3-DICARBOXYLIMIDE
- N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIC ACID IMIDE (HONB)
- N-hydroxynorborn-5-ene-2,3-dicarboximide
- N-Hydroxy-5-norbornene- 2,3-dicarboxylicacid imide,endo-N-Hydroxy-5- norbornene-2,3-dicarboximide
- N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE (HONB)
- N-HYDROXY-5-NORBONENE-2,3-DICARBOXYLIC IMIDE
- N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis]
- N-Hydroxy-5-norbornene-2,3-dicarboximide USP/EP/BP
- TIANFU-CHEM 21715-90-2 N-Hydroxy-5-norbornene-2,3-dicarboximide
- 4-hydroxy-4-azatricyclo[5.2.1.02,]dec-8-ene-3,5-dione
- N-Hydroxy-5-norbornene-2,4-dicarboximide
- N-hydroxy-5-norbornene-2.3-dicarboxylimide(HONB)
- N-Hydroxy-5-norbornene-2,3-dicarboximide[forPeptideSynthesis]>
- N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIC ACID IMIDE
- HONB
- 2-Hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione
- N-Hydroxy-5-Norbornene-2,3-dimethylimide
- 21715-90-2
- 5C9H9NO3
- Synthetic Reagents
- Coupling
- Coupling Reactions (Peptide Synthesis)
- Peptide Synthesis
- Condensation & Active Esterification
- Active Esters/Additives
- Coupling Reagent
- Medical Intermediates
- Biochemistry
- Condensation & Active Esterification
- Coupling Reactions (Peptide Synthesis)
- Peptide Synthesis
- Synthetic Organic Chemistry
