Anti-Atg7 antibody, Mouse monoclonal Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Monoclonal Anti-Atg7 antibody produced in mouse has been used in:
- immunofluorescence
- immunohistochemistry (IHC)
- western blotting
- immunoprecipitation
Allgemeine Beschreibung
Autophagy related 7 (ATG7) is encoded by the gene mapped to human chromosome 3p25.3. The encoded protein has ubiquitous expression.
Biochem/physiol Actions
Atg7 can activate all three Atg8 mammalian homologues, (Golgi-associated ATPase enhancer of 16 kDa (GATE-16), GABA receptor-associated protein (GABARAP) and microtubule-associated protein light chain 3 (MAP-LC3). It forms a homodimer through the C-terminal region that is important for enzyme substrate interaction and E1-E2 complex formation. Atg7 was found to be essential for amino acid supply in neonates and starvation? induced bulk degradation of proteins and organelles in mice. Loss of Atg7 results in the accumulation of abnormal organelles and ubiquitin positive aggregates and leads to neurodegeneration.
Anti-Atg7 antibody, Mouse monoclonal Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
