Bis[2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,4-diphenylcyclobutan-1,3-dicarboxylat, stereoisomer Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

From the leaves of Erythroxylon truxillense Rusby, Hesse isolated an amorphous alkaloid which he designated Cocamine. This was subsequently shown by Liebermann to be a mixture of two isomeric bases and, although the pure alkaloids have not yet been obtained from the alkaloidal mixture owing to difficulties in their separation, each has been prepared synthetically. This particular alkaloid is an amorphous white powder which is soluble in all organic solvents except light petroleum and also insoluble in H20. Solutions of the base are alllaevorotatory and have an intensely bitter taste. Acid hydrolysis with dilute HCl yields MeOH, (-)-ecgonine and Q-truxillic acid, m.p. 228°C. The alkaloid is synthesized by the action of α-truxillic anhydride on (-)-ecgonine followed by methylation of the resulting α-truxilloylecgonine.

Einzelnachweise

Hesse., Pharm. Zeit., 407,668 (1887)
Liebermann., Ber., 21,2342 (1888)
Hesse., ibid, 22, 665 (1889)
Liebermann, Drory., ibid, 22,682 (1889)

Bis[2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,4-diphenylcyclobutan-1,3-dicarboxylat, stereoisomer Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Bis[2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,4-diphenylcyclobutan-1,3-dicarboxylat, stereoisomer Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8447	60
Zhuhai Anzhe Biotechnology Co,Ltd.	13169972583	513211116@qq.com	China	3006	58
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Aikon International Limited	18651614124	2881516338@qq.com	China	9199	58

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• a-Truxilline
• bis[2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] 2,4-diphenylcyclobutane-1,3-dicarboxylate, stereoisomer
• EINECS 207-707-5
• 2,4-Diphenyl-1,3-cyclobutanedicarboxylic acid bis[2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester
• 2,4-di(phenyl)cyclobutane-1,3-dicarboxylic acid bis[(1R,2R,3S,5S)-2-carbomethoxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester
• bis[(1R,2R,3S,5S)-2-methoxycarbonyl-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2,4-di(phenyl)cyclobutane-1,3-dicarboxylate
• α-Truxilline
• bis[(1R,2R,3S,5S)-2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl](1r,2c,3t,4t)-2,4-diphenylcyclobutane-1,3-dicarboxylate(α-truxilline)
• 490-17-5