roflamycoin Chemische Eigenschaften,Einsatz,Produktion Methoden

Synthese

For Rychnovsky and co-worker’s synthesis of roflamycoin (45), the hemiketal-pyran linkage required differential substitution (Scheme 9) and demonstrated the power of the sequential double addition strategy.14 Treatment of bis-epoxide S,S-4 with a stoichiometric amount of (benzyloxy)methyllithium 38 and BF3?OEt2 in THF at –78 °C provided monoaddition adduct 39, which was then treated with the organolithium formed from transmetallation of 2,2-bis-(tributyltin)dithiane 40. This single-pot procedure afforded dithiane diol 41 in 56% overall yield. Subsequent acetonide formation and transmetallation provided a competent nucleophile for direct displacement of dibromide 42, which itself was derived from dichlorodiol R,R-3. The resulting bis-acetonide (43) was obtained in 60% overall yield and provided a rapid access to tris-acetonide 44, a key intermediate for the synthesis of the hemiketal-pyran moiety of 45. Similar sequential addition strategies have proven to be useful as well.

roflamycoin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

roflamycoin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19741	58
Zhejiang Huida Biotech Co., LTD	0571-89903882 13626641628	jiangnan@huidabiotech.com	China	3656	58
Zhejiang Huida Biotech Co., LTD	0571-0571-89903882 15990081639	sunshixuan@huidabiotech.com	China	3705	58

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• 14,37-Dioxabicyclo[31.3.1]heptatriaconta-3,5,7,9,11-pentaen-13-one, 19,21,23,25,27,29,31,33,35-nonahydroxy-12,16-dimethyl-15-(1-methylethyl)-, (1R,3E,5E,7E,9E,11E,15S,16S,19S,21S,23S,25R,27R,29S,31R,33S,35S)- (9CI)
• Roflamycoin
• 77814-07-4