天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Alflutinib

Alflutinib Struktur
1869057-83-9
CAS-Nr.
1869057-83-9
Englisch Name:
Alflutinib
Synonyma:
Aflutinib;ASK120067;Alflutinib;Capsaicin Impurity 17;Firmonertinib Alflutinib;Alflutinib, 10 mM in DMSO;Alflutinib (Firmonertinib);AST2818;AST-2818;ASK120067;Alflutinib,inhibit,esistant mutation,T790M,EGFR,AST 2818,Furmonertinib,Inhibitor,ErbB-1,NSCLC,cancer,Epidermal growth factor receptor,AST-2818,HER1;N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)prop-2-enamide
CBNumber:
CB84844457
Summenformel:
C28H31F3N8O2
Molgewicht:
568.61
MOL-Datei:
1869057-83-9.mol

Alflutinib Eigenschaften

Dichte
1.29±0.1 g/cm3(Predicted)
Aggregatzustand
Solid
pka
11?+-.0.70(Predicted)
Farbe
White to off-white

Sicherheit

Alflutinib Chemische Eigenschaften,Einsatz,Produktion Methoden

Mechanism of action

As a third-generation EGFR TKI, Alflutinib can irreversibly bind to the EGFR protein, especially to tumor cells carrying the T790M drug-resistant mutation. This specific binding helps reduce damage to normal cells while effectively inhibiting the proliferation of tumor cells.

Synthese

Arylation of the indole prepared the chloropyridine 21.7, which was then reacted with the aniline 21.4 in the presence of excess p-toluenesulfonic acid to produce 21.8 (see Figure 7.3.2). The second SNAr reaction used the diamine 21.9, which was coprecipitated with water in DMF to give the amine 21.10 in 77% yield over a two-step reaction. Reduction of the nitro group using sodium sulfite gave the corresponding amine under metal-free and mild conditions. The crude aniline was then converted to the dihydrochloride salt 21.11, which was isolated as a solid in high purity (99.8%) and yield (94%) after slurrying in methanol and ethanol. Finally, a two-step approach was used to install the α,β-unsaturated amide, as opposed to the earlier route that used acryloyl chloride directly. The acylation reaction used the chloroacyl chloride 21.12 to give the alkyl chloride 21.13, which was isolated by filtration. Subsequently, an elimination reaction was carried out with triethylamine at reflux in acetonitrile to prepare alflutinib (21) in 93% yield and 99.2% purity.
Alflutinib

Alflutinib Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Alflutinib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 31)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+17819995354
marketing@targetmol.com United States 32283 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6312 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58
Wuhan Jingkang en Biomedical Technology Co., Ltd
+8613720134139
orders@jknbiochem.com China 5221 58
Shanghai Hanhong Scientific Co., Ltd.
+undefined17612118332
Lucky@hanhonggroup.com China 6035 58
CAREBIO PHARMA 18501057619 18501057619
jackyfan@rebornpharma.com China 238 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696,15000506266 15000506266
China 4621 55
Shanghai Send Pharmaceutical Technology Co., Ltd. 021-58088081 Q2816483246
danping@shsendpharm.com China 3092 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9803 58
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686
sales@rechemscience.com China 2983 58

  • Alflutinib
  • ASK120067
  • AST2818;AST-2818;ASK120067
  • 2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-6-(2,2,2-trifluoroethoxy)-3-pyridinyl]-
  • Alflutinib,inhibit,esistant mutation,T790M,EGFR,AST 2818,Furmonertinib,Inhibitor,ErbB-1,NSCLC,cancer,Epidermal growth factor receptor,AST-2818,HER1
  • Firmonertinib Alflutinib
  • N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)prop-2-enamide
  • Capsaicin Impurity 17
  • Alflutinib, 10 mM in DMSO
  • Alflutinib (Firmonertinib)
  • Aflutinib
  • 1869057-83-9
  • C28H31F3N8O2
Copyright 2019 ? ChemicalBook. All rights reserved