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Thioacetazon

THIACETAZONE Struktur
104-06-3
CAS-Nr.
104-06-3
Bezeichnung:
Thioacetazon
Englisch Name:
THIACETAZONE
Synonyma:
tbi;TB 1;Tb I;Antib;Tibon;Tubin;Diazan;Diasan;Ilbion;Thibon
CBNumber:
CB8422936
Summenformel:
C10H12N4OS
Molgewicht:
236.29
MOL-Datei:
104-06-3.mol

Thioacetazon Eigenschaften

Schmelzpunkt:
225-230 °C
Dichte
1.2752 (rough estimate)
Brechungsindex
1.6440 (estimate)
storage temp. 
Store at -20°C
L?slichkeit
Soluble in DMSO
pka
11.35±0.70(Predicted)
Aggregatzustand
powder to crystal
Farbe
White to Orange to Green
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
S-S?tze: 36
WGK Germany  3
RTECS-Nr. AE3850000
HS Code  29309090
Toxizit?t LD50 s.c. in mice: 1-2 g/kg (Bavin)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P332+P313 Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P337+P313 Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Thioacetazon Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.

S-S?tze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

Solid

Verwenden

Thiacetazone (cas# 104-06-3) is used in combination chemotherapy, in preparation of nucleosides as inhibitors of adenylate-forming enzyme MenE.

Indications

Thiacetazone is active against many strains of M. tuberculosis. It is not marketed in the United States. However, because of its low cost, it is used as a first-line agent in East Africa, especially in combination with compounds such as isoniazid. The most common side effects of thiacetazone include GI intolerance and development of rashes. It causes significant ototoxicity, especially when coadministered with streptomycin. Lifethreatening hypersensitivity reactions, such as hepatitis, transient marrow aplastic syndromes, neutropenia, and thrombocytopenia, have been reported.

Pharmazeutische Anwendungen

Thioacetazone (USAN amithiozone) is a synthetic compound discovered during initial work on the sulfonamides, to which it is structurally related. It is only slightly soluble in water. It is a weak bacteristatic drug, with frequent serious side effects, particularly in HIV-positive persons to whom it must never knowingly be given. On the advice of the WHO it no longer has a place in the treatment of tuberculosis, except as a last resort in cases of extreme drug resistance.
In-vitro MICs vary considerably according to the medium used and bear little relation to in-vivo efficacy. Many strains of M. tuberculosis isolated in East Africa, India and Hong Kong are naturally more resistant than strains from Europe. Acquired resistance, as a result of monotherapy, is prevalent in the developing countries.
Thioacetazone is well absorbed, achieving a plasma concentration of 1–4 mg/L 2–4 h after a 100 mg oral dose. The plasma half-life is 8–12 h. Little is known about the distribution of the drug. Several metabolites are described. About 20% is eliminated in the urine; the fate of the remainder is unknown. Rashes are common, occurring in 2–4% of patients in Africa but much more frequently in those of Chinese ethnic origin. More severe skin reactions, exfoliative dermatitis and Stevens–Johnson syndrome occur in less than 0.5% of HIV-negative patients, but there is a 10-fold increase of these reactions in HIV-positive patients, proving fatal in up to 3% of such patients. Other common side effects include gastrointestinal reactions, vertigo and conjunctivitis. Less common reactions include hepatitis, erythema multiforme, hemolytic anemia and, rarely, agranulocytosis. Prolonged therapy may rarely lead to hypertrichosis, gynecomastia and osteoporosis. It is very rarely used, but may occasionally be considered (with other antituberculosis drugs) in extremely drug resistant tuberculosis.

Thioacetazon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Thioacetazon Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 115)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29811 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6312 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15352 58
Hefei Hirisun Pharmatech Co., Ltd
+8615056975894
shawn@hirisunpharm.com CHINA 9911 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com China 52849 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58
Shaanxi Didu New Materials Co. Ltd
+86-89586680 +86-13289823923
1026@dideu.com China 8670 58
Nanjing Doge Biomedical Technology Co., Ltd
+86-25-58227606 +86-15305155328
sales@dogechemical.com China 4128 58

104-06-3(Thioacetazon)Verwandte Suche:


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  • Benzothiozon
  • Berculon A
  • berculona
  • Berkazon
  • CBC 903150
  • Conteben
  • Diasan
  • Diazan
  • domagk’st.b.1conteben
  • Domagk's t.b.1 conteben
  • Domakol
  • Ilbion
  • Livazone
  • magk’st.b.1conteben
  • Magk'S T.B.1 conteben
  • Mirizone neustab
  • Mivizon
  • Myvizone
  • n-(4-(((aminothioxomethyl)hydrazono)methyl)phenyl)-acetamid
  • N-(4-((E)-[2-(Aminocarbothioyl)hydrazono]methyl)phenyl)acetamide
  • Neotibil
  • Neustab
  • Novakol
  • Nuclon argentinian
  • nuclonargentinian
  • p-Acetamidobenzaldehyde thiosemicarbazon
  • p-Acetamidobenzaldehyde thiosemicarbazone
  • tb1(bayer)
  • tbi
  • tbi/698
  • Tebalon
  • Tebecure
  • Tebemar
  • Tebesone I
  • tebesonei
  • Tebethion
  • Tebethione
  • Tebezon
  • Thiacetone
  • Thiacetozone
  • Thibon
  • Thibone
  • Thioacetazon
  • Thioacetazone
  • Thioazetazone
  • Thiomicid
  • Thionicid
  • Thioparamizon
  • Thioparamizone
  • Thiosemicarbarzone
  • Thiosemicarbazone
  • P-ACETAMINOBENZALDEHYDE THIOSEMICARBAZONE
  • THIOCARBAZIL
  • THIACETAZON
  • 4’-formyl-acetanilid4’-(thiosemicarbazone)
  • 4207 RP
  • 4207rp
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