KETANSERIN TARTRATE
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- CAS-Nr.
- 83846-83-7
- Englisch Name:
- KETANSERIN TARTRATE
- Synonyma:
- kjk-945;R 41468;R41468 tartrate;Ketanserin Tartrat;Ketanserinetartrate;KETANSERIN TARTRATE;R 41468 TARTRATE SALT;quinazoline-2,4(1H,3H);KETANSERIN TARTRATE SALT;3-(2-(4-(4-Fluorobenzoyl)
- CBNumber:
- CB8415888
- Summenformel:
- C26H28FN3O9
- Molgewicht:
- 545.52
- MOL-Datei:
- 83846-83-7.mol
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KETANSERIN TARTRATE Eigenschaften
- Schmelzpunkt:
- 183~186℃
- storage temp.
- 2-8°C
- L?slichkeit
- ethanol: 3.3mg/mL
- Aggregatzustand
- solid
- Farbe
- white
- Wasserl?slichkeit
- Soluble to 10 mM in water
- CAS Datenbank
- 83846-83-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher |
T |
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R-S?tze: |
25 |
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S-S?tze: |
22-36/37/39-45 |
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RIDADR |
UN 2811 6.1/PG 3 |
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WGK Germany |
3 |
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RTECS-Nr. |
VA1411195 |
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HazardClass |
6.1 |
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HS Code |
29335990 |
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Toxizit?t |
LD50 oral in rat: 129mg/kg |
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Bildanzeige (GHS) |
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Alarmwort |
Achtung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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Sicherheit |
P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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KETANSERIN TARTRATE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Beschreibung
Ketanserin is a potent antagonist of the serotonin (5-HT) receptor that is selective for 5-HT
2 (IC
50 = 6.3 nM; K
i = 2.1 nM). It has no activity at 5-HT
1 receptors but does have activity at histamine type 1, α
1-adrenergic, and dopamine receptors with K
i values of 10, 10, and 220 nM, respectively. Ketanserin induces dose-dependent inhibition of contractile responses to 5-HT in isolated rat caudal artery, canine basilar, carotid, coronary and gastrosplenic arteries, and canine gastrosplenic and saphenous veins. Ketanserin (10 mg/kg/day) significantly decreases blood pressure (BP), blood pressure variability (BPV), and hypertensive organ damage in spontaneously hypertensive rats. Formulations containing ketanserin have been used to treat hypertension in early-onset preeclampsia.
Verwenden
coccidiostat
Biologische Aktivit?t
Selective 5-HT 2A serotonin receptor antagonist; can also be used to discriminate between 5-HT 1D and 5-HT 1B receptor subtypes.
KETANSERIN TARTRATE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
KETANSERIN TARTRATE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 140)Lieferanten
83846-83-7()Verwandte Suche:
- R 41468
- R 41468 TARTRATE SALT
- 3-(2-(4-(p-fluorobenzoyl)-1-piperidinyl)ethyl)-2,4(1h,3h)-quinazolinedionel
- 4(1h,3h)-quinazolinedione,3-(2-(4-(4-fluorobenzoyl)-1-piperidinyl)ethyl)-(
- kjk-945
- r-(r*,r*))-2,3-dihydroxybutanedioate(1:1)
- 3-[2-[4-(4-fluorobenzoyl)piperidino]ethyl]quinazoline-2,4(1H,3H)-dione [R-(R*,R*)]-tartrate
- KETANSERIN TARTRATE (R 41468) (SELECTIVE 5-HT2/5-HT1C SEROTONI
- Ketanserinetartrate
- R 41468 (+)-tartrate salt, 3-(2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl)-2,4(1H,3H)-quinazolinedione (+)-tartrate salt
- 3-[2-[4-(4-Fluorobenzoyl)piperidino]ethyl]-2,4-(1H,3H)-quinazolinedione tartrate
- Ketanserin Tartrat
- 3-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)quinazoline-2,4(1H,3H)-dione 2,3-dihydroxysuccinate
- 3-(2-(4-(4-Fluorobenzoyl)
- -dione 2,3-dihydroxysuccinate
- quinazoline-2,4(1H,3H)
- Ketanserin tartrate salt Morpholino
- 3-[2-(4-FLUOROBENZOYL)-1-PIPERDINYL]-ETHYL]-2,4(1H,3H)-QUINAZOLINEDIONE TARTRATE
- 3-[2-[4-(4-FLUOROBENZOYL)-1-PIPERDINYL]ETHYL]-2,4(1H,3H)-QUINAZOLINEDIONE
- 3-[2-[4-(4-FLUOROBENZOYL)-1-PIPERDINYL]ETHYL]-2,4(1H,3H)-QUINAZOLINEDIONE TARTRATE
- 3-[2-[4-(4-FLUOROBENZOYL)-1-PIPERIDINYL]ETHYL]-2,4[1H,3H]-QUINAZOLINEDIONE TARTRATE
- 3-(2-[4-(4-FLUOROBENZOYL)-1-PIPERIDINYL]ETHYL)-2,4(1H,3H)-QUINAZOLINEDIONE TARTRATE SALT
- KETANSERIN TARTRATE
- KETANSERIN TARTRATE SALT
- R41468 tartrate
- 3-[2-[4-[(4-fluorophenyl)-oxomethyl]-1-piperidin-1-iumyl]ethyl]-1H-quinazoline-2,4-dione
- Ketanserin tartrate (R41468 tartrate)
- Ketanserin Tartrate - CAS 83846-83-7 - Calbiochem
- Ketanserin Hydrogen Tartrate
- 2,4(1H,3H)-Quinazolinedione,3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-,(2R,3R)-2,3-dihydroxybutanedioate (1:1)
- 3-(2-(4-(4-Fluorobenzoyl)piperidin-1-yl)ethyl)quinazoline-2,4(1H,3H)-dione (2R,3R)-2,3-dihydroxysuccinate
- (.+-.)-TARTARIC ACID KETANSERIN HYDRATE
- 83846-83-7
- C22H22FN3O3C4H6O6
- C26H28N3O9F
- C4H6O6C22H22FN3O3
- C26H28FN3O9
- Biochemicals and Reagents
- Enzyme Inhibitors
- Other
- Enzymes, Inhibitors, and Substrates
- Enzyme Inhibitors by Type
- BioChemical
- Serotonin
- Cardiovascular APIs
- Serotonin receptor