Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Boc-(R) -3-amino-4 -(2,4, 5-trifluorophenyl) butyric acid is an important intermediate for the preparation of sitagliptin. Sitagliptinphosphate is the first dipeptidase -IV(dpp-4) inhibitor approved by FDA in 2006. It is used for the treatment of type II diabetes mellitus. It has obvious hypoglycemic effect when used alone or in combination with metformin and pioglitazone, and it is safe to take, well tolerated, with few adverse reactions.

Verwenden

(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid has been used as a reactant for the preparation of dipeptidyl peptidase-4 (DPP4) inhibitors for the treatment of type 2 diabetes, such as sitagliptin.

Synthese

(R)-β-tert-butoxycarbonylamino-2,4,5-trifluorophenylbutyric acid ethyl ester could used as a starting material and followed by adding Methanol and LiOHH2O as reaction reagents. Adding dichloromethane to the concentrate and adjust the pH to 2 with 2N HCl. Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid could be obtained through further purification.

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Allfluoro pharmaceutical co. ltd.	021-26137118 +8615821363818	sales@allfluoro.com	China	5790	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8810	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12834	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5889	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	988	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1001	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18751	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58

486460-00-8()Verwandte Suche:

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• Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,(bR)-
• (R)-Sitagliptin N-Boc-Acid IMpurity
• Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid (3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid
• Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid, >=99%
• (3R)-N-Boc-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid
• (3R)-N-(tert-Butoxycarbonyl)-3-aMino-4-(2,4,5-trifluorophenyl)-butanoic acid- Boc-(R)-3-AMino-4-(2,4,5-trifluorophenyl) butanoic acid (BOC acid)
• [[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-(R)-benzenebuta
• BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID
• (3R)-N-(TERT-BUTOXYCARBONYL)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOIC ACID
• (R)-Boc-3-Amino-4-(2,4,5-trifluorophenyl)butanoicacid
• Sitagliptin Intermediate 1
• [[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-(R)-benzenebutanoic acid
• (3R)-N-(TERT-BUTOXYCARBONYL)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BU
• 3(R)-tert-ButoxycarbonylaMino-4-(2,4,5-trifluoro-phenyl)-butyric acid
• (3R)-3-(1,1-Dimethylethoxy carbonyl) amino]- 4-(2,4,5-trifluorophenyl) butanoic acid
• Sitagliptin interMediate
• (R)-N-Boc-3-AMino-4-(2,4,5-trifluorophenyl)butanoic 
• (3R)-3-((1,1-DIMETHYLETHOXYCARBONYL)AMINO)-4-(2,4,5-TRIFLUROPHENYL)-BUTANOIC ACID
• (R)-3-(Boc-aMino)-4-(2,4,5-trifluorophenyl)butanoic acid
• 4-(6-{[(tert-butoxy)carbonyl]aMino}-1,2,5-trifluorocyclohexa-2,4-dien-1-yl)butanoic acid
• Parecoxib SodiuM API
• Sitagliptin interMediateB
• (3R)-3-{[(tert-butoxy)carbonyl]amino}-4-(2,4,5-trifluorophenyl)butanoic acid
• Sitagliptin impurity 19/(R)-Sitagliptin N-Boc-Acid Impurity/(R)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid
• Sitagliptin Impurity 19 ((R)-Sitagliptin N-Boc-Acid Impurity)
• Sitagliptin Acid Boc Impurity (Impurity A)
• BOC- Butanoic Acid
• BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENY
• Sitagliptin Impurity 78
• Sitagliptin N-BOC Carboxylic acid Impurity
• (Tert-Butoxy)Carbonyl (R)-3-Amino-4-(2,4,5-trifluoro-phenyl)-butyric acid
• Sitagliptin Impurity 19
• (3R)-N-Boc-3-amin
• (3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-trifluoro phenyl)butanoic acid [Sita Acid]
• Sitagliptin N-BOC Carboxylic Acid
• Benzenebutanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-, (βR)-
• Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-ButyricAci
• SITAGLIPTIN CAS 654671-78-0 INTERMEDIATES
• BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID ISO 9001：2015 REACH
• Sitagliptin EP Impurity 15
• 5-TRIFLUORO-PHENYL)-BUTYRIC ACID
• BOC-(R)-3-AMINO-4-(2
• N-Boc Sitagliptin Acid Impurity
• Sitagliptin Imp-1(sitagliptin Impurity-A)
• [[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-(R)-be...
• Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
• (R)-N-Boc-3-AMino-4-(2,4,5-trifluorophenyl)butanoic acid
• (R)-3-((tert-Butoxycarbonyl)aMino)-4-(2,4,5-trifluorophenyl)butanoic acid
• (R)-3-(Tert-Butoxycarbonyl)-4-(2,4,5-Trifluorophenyl)Butanoic Acid
• Boc-(R)-3-Amino-4-(2,4,5-Trifluorophenyl)Butanoic Acid / Sitagliptin Intermediate
• (βR)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-2,4,5-trifluorobenzenebutanoic acid
• Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid (Boc acid)
• Benzenebutanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-, (βR)-
• (3R) - N - (tert butoxycarbonyl) -3-amino-4- (2,4,5-trifluorophenyl) butyric acid
• BOC-(R-)3-Amino-4(2,4,5-triflurophenyl)Butanoic acid
• Boc-(R)-3-Amino-4-(2,4,5-trifluorphenyl)butanoic acid
• 4-(2,4-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butane-1,3-dione
• Sitagliptin Impurity 19 (R)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5- trifluorophenyl)butanoic acid