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Tocofersolan

Tocofersolan Struktur
9002-96-4
CAS-Nr.
9002-96-4
Englisch Name:
Tocofersolan
Synonyma:
tpgs;VITAMIN E TPGS;Vitamin E polyethylene glycol succinate;d-alpha-tocopheryl polyethylene glycol succinate;Tocophersolan;D-α-Tocopherol polyethylene glycol succinate;tocopherosolan;D-a-Tocopherol Polyethylene Glycol Succinate;d-alpha-tocopherylpoly(ethyleneglycol)1000succinate;D-a-Tocopherol Polyethylene Glycol Succinate (Vitamin E TPGS)
CBNumber:
CB8396198
Summenformel:
(C2H4O)nC33H54O5
Molgewicht:
0
MOL-Datei:
9002-96-4.mol

Tocofersolan Eigenschaften

Schmelzpunkt:
34-38°C
storage temp. 
2-8°C
L?slichkeit
H2O: soluble1g/10 mL, clear to faintly turbid, colorless to faintly yellow
Aggregatzustand
Solid
Farbe
White to Pale Yellow Waxy
InChI
InChI=1S/C34H56O6/c1-23(2)12-9-13-24(3)14-10-15-25(4)16-11-20-34(8)21-19-29-28(7)32(26(5)27(6)33(29)40-34)39-31(37)18-17-30(36)38-22-35/h23-25,35H,9-22H2,1-8H3
InChIKey
WFWQYXBTWIHIIW-UHFFFAOYSA-N
SMILES
C(=O)(OC1C(C)=C2CCC(C)(CCCC(CCCC(CCCC(C)C)C)C)OC2=C(C)C=1C)CCC(=O)OCO
LogP
9.745 (est)

Sicherheit

WGK Germany  2
RTECS-Nr. TR1581200
HS Code  2936.28.0000

Tocofersolan Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Vitamin E polyethylene glycol succinate is a synthetic product. It is available as a white to light-brown, waxy solid and is practically tasteless. Chemically, it is a mixture composed principally of monoesterified polyethylene glycol 1000, the diesterified polyethylene glycol 1000, free polyethylene glycol 1000, and free tocopherol.

Vorbereitung Methode

Vitamin E polyethylene glycol succinate is prepared by esterification of the acid group of crystalline D-a-tocopheryl acid succinate by polyethylene glycol 1000.

Pharmazeutische Anwendungen

Vitamin E polyethylene glycol succinate is an esterified vitamin E (tocopherol) derivative primarily used as a solubilizer or emulsifying agent because of its surfactant properties. Structurally, it is amphipathic and hydrophilic, unlike the tocopherols, and therefore it is a water-soluble derivative that can be used in pharmaceutical formulations such as capsules, tablets, hot-melt extrusion, microemulsions, topical products, and parenterals. One of the most important applications is its use as a vehicle for lipid-based drug delivery formulations. It can also be used as a source of vitamin E.
Vitamin E polyethylene glycol succinate has been characterized with respect to its mechanism of action and studied as a Pglycoprotein inhibitor.

Sicherheit(Safety)

Vitamin E polyethylene glycol succinate has been used at levels of 280 mg/capsule in the product Agenerase (amprenavir), which was dosed at 8 capsules (2240mg vitamin E TPGS) per day. An additional assessment of the safety of vitamin E polyethylene glycol succinate has been published, which includes a report showing no-observed-adverse-effect-level (NOAEL) in rats of 1000 mg/kg/day.

Lager

Vitamin E polyethylene glycol succinate is stable at ambient room temperature for up to 4 years. It reacts with alkalis and acids. Aqueous solutions of vitamin E polyethylene glycol succinate are stable over a pH range of 4.5–7.5 and can be further stabilized with propylene glycol.

Inkompatibilit?ten

Vitamin E polyethylene glycol succinate is incompatible with strong acids and strong alkalis.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (ophthalmic solution or drops; oral capsules, solution, tablet; topical solution or drops). Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Tocofersolan Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Tocofersolan Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 271)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi LonierHerb Bio Technology Co Ltd
+86-86-+86-86-029-87551862 +8617702909819
sales006@ingredients-lonier.com China 2608 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18151 58
Hebei Kingfiner Technology Development Co.Ltd
+86-15532196582 +86-15373005021
lisa@kingfinertech.com China 3010 58
Shaanxi Haibo Biotechnology Co., Ltd
+undefined18602966907
qinhe02@xaltbio.com China 997 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20284 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651
admin@zlchemi.com China 3002 58
Hebei Mojin Biotechnology Co.,Ltd
+86-15028179902
angelia@hbmojin.com China 1176 58

9002-96-4()Verwandte Suche:


  • DL-A-TOCOPHEROL POLYETHYLENE GLYCOL SUCCINATE
  • DL-ALPHA-TOCOPHEROL POLYETHYLENE GLYCOL SUCCINATE
  • tocofersolan
  • 2-ethanediyl),.alpha.-[4-[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzoPoly(oxy-1
  • poly(oxy-1,2-ethanediyl),alpha-(4-((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12
  • dl-alpha-Tocopherol Polethylene Glycol Succinate
  • D-α-Tocopheryl polyethylene glycol succinate
  • Poly(oxy-1,2-ethanediyl), .alpha.-4-(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-(4R,8R)-4,8,12-trimethyltridecyl-2H-1-benzopyran-6-yloxy-1,4-dioxobutyl-.omega.-hydroxy-
  • D-ALPHA-TOCOPHEROLPOLYETHYLENEGLYCOL-1000-SUCCINATE
  • ALPHA-TOCOPHEROLPOLYETHYLENEGLYCOL1000SUCCINATE
  • D-α-Tocopherol polyethylene glycol 1000 succinate
  • Poly(oxy-1,2-ethanediyl), alpha-(4-((3,4-dihydro-2,5,7,8-tetramethyl-2- (4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)-1,4-dioxobutyl)-omega-hydroxy-, (2R-(2R*(4R*,8R*)))
  • alpha-Tocopheryl poly(ethylene glycol) 1000 succinate, D-
  • alpha-Tocopheryl poly(ethylene glycol)1000 succinate, D-
  • Tocofersolan [inn]
  • TPGS-VE
  • 4-dioxobutyl)-omega-hydroxy--trimethyltridecyl)-2h-1-benzopyran-6-yl)oxy)-
  • 8r*)))-(2r-(2r*(4r
  • alpha-tocopherylpolyethyleneglycolsuccinate
  • d-.alpha.-Tocopherylpoly(ethyleneglycol)1000succinate
  • d1t
  • Poly(oxy-1,2-ethanediyl),.alpha.-[4-[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-.omega.-hydroxy-,[2R-[2R*(4R*,8R*)]]-
  • [2R-[2R*(4R*,8R*)]]-α-[4-[[3,4-dihydro-2,5,7,8-tetraMethyl-2-(4,8,12-triMethyltridecyl)-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-ω-hydroxypoly(oxy-1,2-ethanediyl)
  • Mono[2,5,7,8-tetraMethyl-2-(4,8,12-triMethyltridecyl)-6-chroManyl] Succinate Polyoxyethylene Ether
  • VitaMin E-TPGS ("tocofersolan")
  • Poly(oxy-1,2-ethanediyl),a-[4-[[(2R)-3,4-dihydro-2,5,7,8-tetraMethyl-2-[(4R,8R)-4,8,12-triMethyltridecyl]-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-w-hydroxy-
  • Tocopheryl PEG succinate
  • d-α-tocopheryl polyethylene glycol succinic acid esters (of TPGS)
  • Tocofersolan,VE-TPGS
  • D-ALPHA-TOCOPHEROL POLYETHYLENE GLYC
  • D-Α-Tocopherol Polyethylene Glycol Succinate ( Tpgs )
  • DL-α-Tocopherol methoxypolyethylene glycol succinate solution (2 wt% in water) TPGS-750-M
  • Tocofersolan(TPGS)
  • Vitamin E Polyethylene Glycol Succinate (TPGS)
  • alpha-Tocopherol Polyethylene Glycol Succinate
  • Tocofersolan9002-96-4
  • D-2-Vitamin E polyethylene glycol succinate
  • D-alpha-Tocopherol polyethylene glycol
  • Factory Supply Vitamin E Polyethylene Glycol Succinate CAS 9002-96-4
  • Polyethylene glycol 1000Q: What is Polyethylene glycol 1000 Q: What is the CAS Number of Polyethylene glycol 1000 Q: What is the storage condition of Polyethylene glycol 1000 Q: What are the applications of Polyethylene glycol 1000
  • Vitamin E Tocofersolan
  • α-Tocopherol Polyethylene Glycol Succinate
  • d-alpha-tocopheryl polyethylene glycol succinate
  • alpha-(4-((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2h-1-benzopyran-6-yl)oxy)-1,4-dioxobutanol poly(ethylene glycol) succinate
  • tocopherosolan
  • tpgs
  • Tocophersolan
  • VITAMIN E TPGS
  • D-α-Tocopherol polyethylene glycol succinate, TPGS, Vitamin E polyethylene glycol succinate, Vitamin E-TPGS
  • D-a-Tocopherol Polyethylene Glycol Succinate (Vitamin E TPGS)
  • D-α-Tocopherol polyethylene glycol succinate
  • Vitamin E polyethylene glycol succinate
  • D-a-Tocopherol Polyethylene Glycol Succinate
  • d-alpha-tocopherylpoly(ethyleneglycol)1000succinate
  • Tuoke suolun
  • α-Tocopheryl polyethylene glycol succinate
  • Vitamin E Polyethylene Glycol Succinate (TPGS) /Tocofersolan
  • Vitamin E succinic acid polyethylene glycol ester
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