Anti-ATPase, H+/K+ transporting, nongastric, α polypeptide Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project
(www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these
protocols and other useful information about Prestige Antibodies and the HPA, visit .
Allgemeine Beschreibung
The ATPase H
+/K
+ transporting non-gastricα2 subunit (ATP12A) gene, with 23 exons and 22 introns spanning 32kb of genomic DNA, is mapped to human chromosome 13q12.1-q12.3. ATP12A is a member of P-type cation transport ATPases family. The gene encodes the catalytic alpha subunit of Na
+/K
+-ATPase, which is ubiquitously expressed.
Biochem/physiol Actions
ATPase H+/K+ transporting non-gastric α2 subunit (ATP12A) plays a vital role in the regulation of acid-base and K+ homeostasis in the kidney and colon. In addition, it also aids acidification of prostate secretions in the anterior lobe of the organ and transepithelial bicarbonate secretion in the ducts of the exocrine pancreas. ATP12A mutations might affect myocardial Na+ handling and subsequently myocardial function. Overexpression of ATP12A has been observed in human colorectal carcinoma.
Anti-ATPase, H+/K+ transporting, nongastric, α polypeptide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
