Anti-hCED-12A Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-ELMO2 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project
(www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these
protocols and other useful information about Prestige Antibodies and the HPA, visit .
Allgemeine Beschreibung
The gene ELMO2 (engulfment and cell motility protein 2) is mapped to human chromosome 20q13.12. The protein localizes in the cytoplasm and the plasma membrane.
Biochem/physiol Actions
Engulfment and cell motility protein 2 (ELMO2) interacts with DOCK180 (dedicator of cytokinesis protein). In breast cancer cells, activated RhoG induces translocation of ELMO2-DOCK180 from the cytoplasm to the plasma membrane, leading to activation of RAC1 (Ras-related C3 botulinum toxin substrate 1). Activation of RAC induces lamellipodium formation and cell migration. ELMO2 also interacts with ACF7 (actin cross-linking family protein 7). Together they enhance the formation of membrane protrusions during integrin-induced cell spreading.
Anti-hCED-12A Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
