Ko 143
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- CAS-Nr.
- 461054-93-3
- Englisch Name:
- Ko 143
- Synonyma:
- Ko 143;12aS)-;4-dioxo-;6]pyrido[3;Ko143 ,99%;Pyrazino[1';Ko143 hydrate;KO 143;KO-143;KO143;4-b]indole-3-propanoicacid;12a-octahydro-9-Methoxy-6-(2-Methylpropyl)-1
- CBNumber:
- CB81562442
- Summenformel:
- C26H35N3O5
- Molgewicht:
- 469.57
- MOL-Datei:
- 461054-93-3.mol
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Ko 143 Eigenschaften
- Schmelzpunkt:
- 147 ºC
- Siedepunkt:
- 689.8±55.0 °C(Predicted)
- Dichte
- 1.24
- storage temp.
- Desiccate at -20°C
- L?slichkeit
- DMSO: >10mg/mL
- Aggregatzustand
- powder
- pka
- 13.31±0.60(Predicted)
- Farbe
- white to off-white
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Ko 143 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Breast cancer resistance protein (BCRP) is an ATP-
binding cassette protein known also as ABCG2. While it normally functions as a high-
capacity urate exporter in the renal system, it also acts as a xenobiotic transporter and contributes to multidrug resistance (
e.g., to mitoxantrone) in certain types of cancer. BCRP is abundant at the intestinal epithelium and blood-
brain barrier, potentially restricting the distribution of certain drugs. Ko 143 is a potent and selective inhibitor of BCRP, preventing the export of mitoxantrone and topotecan in breast cancer cell lines (EC
50s = 23 and 26 nM, respectively). It is much less effective at the transporters P-
glycoprotein and multidrug resistance-
associated protein 1, MRP1. Ko 143 is effective
in vivo in mice.
Verwenden
A potent BCRP (breast cancer resistance protein) inhibitor
Biologische Aktivit?t
Potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC 90 = 26 nM). Displays > 200-fold selectivity over P-gp and MRP-1 transporters. Increases intracellular drug accumulation and reverses BCRP-mediated multidrug resistance.
Ko 143 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ko 143 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 99)Lieferanten
461054-93-3()Verwandte Suche:
- Pyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid, 1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxo-, 1,1-dimethylethyl ester, (3S,6S,12aS)-(Ko143)
- Ko 143
- (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester
- 12a-octahydro-9-Methoxy-6-(2-Methylpropyl)-1
- 12aS)-
- 4-b]indole-3-propanoicacid
- 4-dioxo-
- 6]pyrido[3
- Pyrazino[1'
- Ko143 ,99%
- Ko143 hydrate
- tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7, 12,12a-octahydropyrazino[1
- (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-( 2-methylpropyl)-1,4-dioxopyrazino[1′,2′:1,6]pyrido[3,4- b]indole-3-propanoic acid 1,1-dimethylethyl ester hydrate
- tert-butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)propanoate
- KO 143;KO-143;KO143
- tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino
- (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2'
- 1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester
- (3s,6s,12as)-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester
- tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)propanoate
- (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-( 2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4- b]indole-3-propanoic Acid tert-Butyl Ester
- 461054-93-3
- C26H35N3O5
- C26H36N3O5
- Pharmaceuticals
- Chiral Reagents
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
