L-A-HYDROXYGLUTARIC ACID DISODIUM)
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- CAS-Nr.
- 63512-50-5
- Englisch Name:
- L-A-HYDROXYGLUTARIC ACID DISODIUM)
- Synonyma:
- L-2-HG;SKL187;disodium L-2-hydroxyglutarate;Disodium (S)-2-hydroxyglutarate;(S)-2-Hydroxypentanedioic acid;Sodium (S)-2-hydroxypentanedioate;L-2-Hydroxyglutarate DisodiuM Salt;L-α-Hydroxyglutaricaciddisodiumsal;L-2-Hydroxyglutaric acid (disodium);(S)-2-Hydroxyglutaric acid disodium
- CBNumber:
- CB81473690
- Summenformel:
- C5H9NaO5
- Molgewicht:
- 172.11
- MOL-Datei:
- 63512-50-5.mol
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L-A-HYDROXYGLUTARIC ACID DISODIUM) Eigenschaften
- Schmelzpunkt:
- >300°C
- storage temp.
- 2-8°C
- L?slichkeit
- Methanol (Very Slightly), Water (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Optische Aktivit?t
- [α]/D -8.5±1.5°, c = 1 in 0.1 M NaOH
- BRN
- 5318042
Sicherheit
L-A-HYDROXYGLUTARIC ACID DISODIUM) Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels. L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.
Chemische Eigenschaften
White Solid
Verwenden
A potential inhibitor of glutamate carboxypeptidase.
Allgemeine Beschreibung
Glutamic acid is metabolized to α-Hydroxyglutaric acid in an NAD-dependent manner by cell-free extracts of
Peptococcus aerogenes. It is formed as an intermediate during glyoxylic acid metabolism in bacteria.
L-A-HYDROXYGLUTARIC ACID DISODIUM) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
L-A-HYDROXYGLUTARIC ACID DISODIUM) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 76)Lieferanten
- (S)-2-Hydroxypentanedioic acid
- L-α-Hydroxyglutaric acid disodium salt
- (2S)-2-Hydroxyglutaric Acid Disodium Salt
- Pentanedioic acid,2-hydroxy-, disodium salt, (2S)-
- s-2-Hydroxypentanedioic acid disodium salt
- Pentanedioic acid, 2-hydroxy-, sodiuM salt (1:2)
- Disodium (S)-2-hydroxyglutarate
- L-ALPHA-HYDROXYGLUTARIC ACID DISODIU
- (S)-α-Hydroxyglutaric Acid DisodiuM Salt
- L-2-Hydroxyglutarate DisodiuM Salt
- L-alpha-hydroxyglutaric acid, disodium salt
- L-2-Hydroxyglutaric acid (disodium)
- L-α-Hydroxyglutaric Acid (sodium salt)
- Sodium (S)-2-hydroxypentanedioate
- L-a-Hydroxyglutaric acid disodium salt
- L-2-HG
- (S)-2-Hydroxyglutaric acid disodium
- Pentanedioic acid, 2-?hydroxy-?, sodium salt (1:2)?, (2S)?-
- L-α-Hydroxyglutaric acid disodium salt
- SKL187
- L-α-Hydroxyglutaricaciddisodiumsal
- L 2 Hydroxyglutaric acid disodium,modifier,demethylases,methylation,Mitochondrial Metabolism,Histone Demethylase,Inhibitor,renal,cancer,epigenetic,inhibit,histone,L2Hydroxyglutaric acid disodium
- L-α-Hydroxyglutaric Acid (sodium salt)
- disodium L-2-hydroxyglutarate
- 63512-50-5
- C5H6O5Na2
- C5H8Na2O5
- Inhibitors
- Aliphatics
- Chiral Reagents
