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Abiraterone acetate

Abiraterone acetate Struktur
154229-18-2
CAS-Nr.
154229-18-2
Englisch Name:
Abiraterone acetate
Synonyma:
ZYTIGA;17-(3-pyridyl)-5,16-androstadien-3beta-acetate;Abiraterone Acotate;(3)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol Acetate (Ester);(3beta)-17-(3-pyridinyl)-Androsta-5,16-dien-3-ol acetate (ester);[(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate;(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate;CS-212;CB 7630;Abiraterone WS
CBNumber:
CB81396153
Summenformel:
C26H33NO2
Molgewicht:
391.55
MOL-Datei:
154229-18-2.mol

Abiraterone acetate Eigenschaften

Schmelzpunkt:
127-130°C
Siedepunkt:
506.7±50.0 °C(Predicted)
Dichte
1.14±0.1 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
Chloroform (Slightly), DMSO (Sparingly), Methanol (Sparingly)
pka
5.31±0.12(Predicted)
Aggregatzustand
powder
Farbe
white to beige
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  3
RTECS-Nr. BV7992100
HS Code  2937290000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H360 Kann die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" />
H372 Sch?digt bei Hautkontakt und Verschlucken die Organe bei l?ngerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" /> P260, P264, P270, P314, P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Abiraterone acetate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

In April 2011, the United States FDA approved abiraterone acetate (CB7630) in combination with the steroid prednisone for the treatment of metastatic castration-resistant prostate cancer (mCRPC) for patients who were previously treated with a docetaxel containing regimen for late-stage disease. Abiraterone acetate affects prostate, testicular, and adrenal androgens by irreversibly inhibiting both the lyase and hydroxylase activity of cytochrome P450 17A (CYP17) signaling pathways (IC50's of 2.9 and 4 nM, respectively) thereby decreasing testosterone levels.Most common serious adverse events for abiraterone acetate versus placebo included fluid retention (30.5% vs. 22.3%), hypokalemia (17.1% vs. 8.4%), hypertension (9.7% vs. 7.9%), hepatic transaminase abnormalities (10.4% vs. 8.1%), and cardiac abnormalities (13.3% vs. 10.4%).

Chemische Eigenschaften

Off-White Solid

Verwenden

Abiraterone acetate is a novel steroidal inhibitor of human Cytochrome P450 (17α-Hydroxylase-C17,20-lyase): potential agent for the treatment of prostatic cancer.

Definition

ChEBI: A sterol ester obtained by formal condensation of the 3-hydroxy group of abiraterone with the carboxy group of acetic acid. A prodrug that is converted in vivo to abiraterone. Used for treatment of metastatic castrate-resistant prostate cance .

Abiraterone acetate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine Abiraterone (3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate) 3-Pyridylboronic acid DIETHYL(3-PYRIDYL)BORANE 3-Brompyridin 3β-Hydroxyandrost-5-en-17-onacetat

Downstream Produkte

Abiraterone acetate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 574)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Joyochem Co.,Ltd
+86-0531-82687558 +8613290333633
 sales@joyochem.com China 31 58
Hebei Weibang Biotechnology Co., Ltd 		+8615531157085
 abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578
 sales@hbmojin.com China 12835 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177
 peter@yan-xi.com China 5857 58
Hangzhou ICH Biofarm Co., Ltd 		+86-0571-28186870; +undefined8613073685410
 sales@ichemie.com China 1001 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907
 qinhe02@xaltbio.com China 997 58
Jinan Million Pharmaceutical Co., Ltd 		0531-68659554 +8613031714605
 info@millionpharm.com China 252 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858
 daisy@anhuiruihan.com China 973 58
Nantong Guangyuan Chemicl Co,Ltd 		+undefined17712220823
 admin@guyunchem.com China 615 58
hebei hongtan Biotechnology Co., Ltd 		+86-86-1913198-3935 +8617331935328
 sales03@chemcn.cn China 970 58

154229-18-2()Verwandte Suche:

  • Abiraterone acetate 99.5%
  • Abiraterone acetate(CB7630)
  • 3β-acetoxy-17-(3-pyridyl)androsta-5,16-diene
  • 2-((3S,8R,9S,10R,13S,14S)-10,13-diMethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl)acetate
  • Abiraterone acetate ester
  • Androsta-5,16-dien-3-ol,17-(3-pyridinyl)-, acetate (ester), (3b)-
  • Abiraterone Acetate impurity
  • (3β)-17-(3-pyridinyl) androsta-5,16-dien-3-yl acetate
  • Abiraterone acetate, >=99%
  • Abirteroneacetate
  • 2-((3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodec
  • Abiraterone Acetate
  • CB 7630
  • Abiraterone acetate - CB 7630 | JNJ 212082
  • CS-212
  • Androsta-5,16-dien-3-ol,17-(3-pyridinyl)
  • 3-Epi-abiraterone Acetate stereoisomer
  • Abiraterone Acetate >
  • 17-(3-pyridyl)-5,16-androstadien-3beta-acetatee
  • 17-(Pyridin-3-yl)androsta-5,16-dien-3β-yl acetate
  • Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, acetate (ester), (3β)-
  • ABITATERONE ACETATE
  • Abiraterone Impurity 81
  • 3beta-17-(3-Pyridyl)androsta-5,16-dien-3-ol Acetate
  • Abiraterone acetate ISO 9001：2015 REACH
  • (3aS,3bR,7S,9aR,9bS,11aS)-9a,11a-dimethyl-1-(pyridin-3-yl)-3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-yl acetate
  • Abiraterone acetate (USFDA)
  • Abiraterone acetate- USP
  • Abiraterone Acetate CAS 154229-18-2
  • (3β)-17-(3-pyridyl)- androsta-5,16-dien-3-ol-acetate
  • Abiraterone Acetate (Zytiga
  • formerly CB-7598
  • Abiraterone Acetate D4Q: What is Abiraterone Acetate D4 Q: What is the CAS Number of Abiraterone Acetate D4 Q: What is the storage condition of Abiraterone Acetate D4 Q: What are the applications of Abiraterone Acetate D4
  • Abiraterone Acetate (1000818)
  • 8-Dihydroxyquinaldic acid
  • (3beta)-17-(3-pyridinyl)-Androsta-5,16-dien-3-ol acetate (ester)
  • (3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate
  • 17-(3-pyridyl)-5,16-androstadien-3beta-acetate
  • (3)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol Acetate (Ester)
  • ZYTIGA
  • Abiraterone Acotate
  • [(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
  • Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, acetate (ester), (3β)-
  • Abiteron Acetate
  • Abiraterone WS
  • (3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-(3-pyridyl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl Acetate
  • ABIRATERONE ACTATE
  • 154229-18-2
  • 54229-18-2
  • C26H32NO2
  • Inhibitors
  • Inhibitor
  • Final material
  • Anti-cancer & immunity
  • DQM
  • API
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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