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Basifungin

Basifungin Struktur
127785-64-2
CAS-Nr.
127785-64-2
Englisch Name:
Basifungin
Synonyma:
LY-295337;Basifungin;aureobasidin A;Basifungin(AbA);Jin Basidiomycin A;Aureobasidin A (AbA);Aureobasidin A (9CI);Basifungin/Aureobasidin A;Aureobasidin A(Basifungin);Basifungin ISO 9001:2015 REACH
CBNumber:
CB81120091
Summenformel:
C60H92N8O11
Molgewicht:
1101.42
MOL-Datei:
127785-64-2.mol

Basifungin Eigenschaften

Siedepunkt:
1229.1±65.0 °C(Predicted)
Dichte
1.19±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C, protect from light
L?slichkeit
DMSO : 100 mg/mL (90.79 mM; Need ultrasonic)
pka
13.35±0.70(Predicted)
Aggregatzustand
Solid
Farbe
White to off-white
InChIKey
RLMLFADXHJLPSQ-UBDQFPLBNA-N

Sicherheit

Basifungin Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Basifungin, also known as aureuobacidin A, is an orally available cyclic depsipeptide antibiotic produced by Aureobasidium pullulans that is a fungicide at low concentrations. Aureobasidin A inhibits inositol phosphorylceramide synthase, an enzyme that catalyzes a key step in fungal sphingolipid biosynthesis. This may inhibit fungal cell growth.

Definition

ChEBI: Basifungin is a cyclodepsipeptide antibiotic, which is isolated from the filamentous fungus Aureobasidium pullulans R106 and is toxic to yeast at low concentrations (0.1-0.5 ug/ml).

Clinical Use

Aureobasidin A (Basifungin) is a cyclic depsipeptide that is produced byfermentation in cultures of Aureobasidium pullulan.Aureobasidin A acts as a tight-binding noncompetitive inhibitorof the enzyme inositol phosphorylceramide synthase(IPC synthase), which is an essential enzyme for fungalsphingolipid biosynthesis. A unique structural feature of theaureobasidins is the N-methylation of four of seven amide nitrogenatoms. The lack of tautomerism dictated by N-methylationmay contribute to forming a stable solution conformerthat is shaped somewhat like an arrowhead, the presumed biologicallyactive conformation of aureobasidin-A.The pradimycins and benanomycins are naphthacenequinonesthat bind mannan in the presence of Ca2+ to disrupt the cell membrane in pathogenic fungi. Both demonstrate good in vitro and in vivo activity againstCandida spp. and C. neoformans clinical isolates.

Basifungin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Basifungin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 110)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Minbiotech Co., Ltd.
+8617315815539
sales@minbiotech.com CHINA 129 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715
admin@nexconn.com China 10311 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289
contact@trustwe.com China 5738 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10319 58

  • Cyclo[L-Phe-N-methyl-L-Phe-L-Pro-L-aIle-N-methyl-L-Val-L-Leu-N-methyl-β-hydroxy-L-Val-[(3R)-D-Hmp-]-N-methyl-L-Val-]
  • LY-295337
  • Aureobasidin A (9CI)
  • Aureobasidin A (AbA)
  • Basifungin
  • aureobasidin A
  • Cyclo[L-alloisoleucyl-N-methyl-L-valyl-L-leucyl-N,3-dimethyl-L-threonyl-(2R,3R)-2-hydroxy-3-methylpentanoyl-N-methyl-L-valyl-L-phenylalanyl-N-methyl-L-phenylalanyl-L-prolyl]
  • Basifungin/Aureobasidin A
  • Basifungin ISO 9001:2015 REACH
  • Aureobasidin A(Basifungin)
  • Aureobasidin A (9CI) CAS NO.127785-64-2
  • Aureobasidin A,ceramide,inositolphosphorylceramides,Fungal,Inhibitor,intoxication,inhibit,Basifungin
  • Basifungin(AbA)
  • (3S,6S,9S,12S,15R,18S,21S,24S,29aS)-21,24-Dibenzyl-3,15-di((R)-sec-butyl)-12-(2-hydroxypropan-2-yl)-9-isobutyl-6,18-diisopropyl-5,11,17,23-tetramethyloctadecahydro-1H,15H-pyrrolo[1,2-m][1]oxa[4,7,10,13,16,19,22,25]octaazacycloheptacosine-1,4,7,10,13,16,19,22,25-nonaone
  • Jin Basidiomycin A
  • Short stalked streptomycin A (ABA) powder
  • 127785-64-2
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