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Pipacyclin

pipacycline Struktur
1110-80-1
CAS-Nr.
1110-80-1
Bezeichnung:
Pipacyclin
Englisch Name:
pipacycline
Synonyma:
Sieromicin;Pipacicline;Mepicycline;pipacycline;Tetrasolvina;(4S)-4β-Dimethylamino-1,4,4aβ,5,5aβ,6,11,12a-octahydro-3,6α,10,12,12aβ-pentahydroxy-N-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-6-methyl-1,11-dioxo-2-naphthacenecarboxamide;2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-N-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-6-methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-
CBNumber:
CB7928471
Summenformel:
C29H38N4O9
Molgewicht:
586.638
MOL-Datei:
1110-80-1.mol

Pipacyclin Eigenschaften

alpha 
D20 -195° (c = 0.5); D20 -175° (c = 0.5 in methanol)
Siedepunkt:
895.8±65.0 °C(Predicted)
Dichte
1.55±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
Soluble in DMSO
pka
4.50±1.00(Predicted)

Sicherheit

Toxizit?t LD50 i.v. in white mice: 188 mg/kg (Scalvini, Delmonte)

Pipacyclin Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Pipacycline (mepicycline) is a semi-synthetic tetracycline formed by a Mannich condensation of formaldehyde and 4-hydroxyethylpiperazine with tetracycline. The introduction of the piperazine improves bioavailability, but Mannich bases are pro-drugs, converting back to the parent compound. Pipacycline is used commercially as a salt in combination with penicillin V for parenteral use (penimepicycline). The intrinsic in vitro activity and SARs for the amide region of the tetracycline molecule have not investigated extensively. Pipacycline has not been extensively cited in the literature.

Definition

ChEBI: Tetracycline in which a hydrogen attached to the amide nitrogen is substituted by a 4-[(2-hydroxyethyl)piperazin-1-yl]methyl group.

Pipacyclin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Tetracyclin Paraformaldehyde

Downstream Produkte

Pipacyclin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 16)Lieferanten
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Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
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Novachemistry 44-20819178-90 02081917890
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Shanghai Hongye Biotechnology Co. Ltd 400-9205774
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Hubei Xinyang Medical Technology Co., Ltd 15347293736 15347293736
 2853117764@qq.com China 8407 58
Energy Chemical 021-58432009 400-005-6266
 marketing1@energy-chemical.com China 44806 58

1110-80-1(Pipacyclin)Verwandte Suche:

  • (4S)-4β-Dimethylamino-1,4,4aβ,5,5aβ,6,11,12a-octahydro-3,6α,10,12,12aβ-pentahydroxy-N-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
  • Mepicycline
  • Pipacicline
  • Sieromicin
  • Tetrasolvina
  • pipacycline
  • 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-N-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-6-methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-
  • 1110-80-1
  • C29H38N4O9
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