(±)-HIP-A Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
(+/-)-HIP-A is anew AMPA-kainate receptor agonist.
Biologische Aktivit?t
Potent, non-competitive excitatory amino acid transporter (EAAT) blocker. Preferentially inhibits glutamate-induced [ 3 H]D-aspartate release (IC 50 = 1.6 μ M) rather than [ 3 H]L-glutamate uptake (IC 50 = 18 μ M). Moderately selective; displays no affinity for NMDA and metabotropic glutamate receptors, and low affinity for AMPA and kainate receptors (IC 50 values are 43 and 8 μ M respectively).
(±)-HIP-A Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte