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EXANTA

EXANTA Struktur
192939-46-1
CAS-Nr.
192939-46-1
Englisch Name:
EXANTA
Synonyma:
EXANTA;Exarta;CS-1834;H 376/95;Exanta (TN);XIMELEGATRAN;EXANTA/XIMELEGATRAN;Exanta (XiMelagatran);Ximelagatran [USAN:INN];Ximelagatran (H 376/95)
CBNumber:
CB7838374
Summenformel:
C24H35N5O5
Molgewicht:
473.57
MOL-Datei:
192939-46-1.mol

EXANTA Eigenschaften

Schmelzpunkt:
65-68?C
Dichte
1.35±0.1 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
DMSO : 250 mg/mL (527.91 mM; Need ultrasonic)Methanol : 62.5 mg/mL (131.98 mM; Need ultrasonic)
pka
6.87±0.69(Predicted)
Aggregatzustand
powder
Farbe
white to beige
Stabilit?t:
Hygroscopic

Sicherheit

EXANTA Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Ximelagatran is an ester prodrug of melagatran, a potent, direct, and reversible thrombin inhibitor (Ki = 1.2 nM). While melagatran has poor oral bioavailability, ximelagatran displays good bioavailability resulting, in part, from rapid absorption at the gastrointestinal tract, as well as rapid onset of action. Ximelagatran is converted to melagatran by reduction and hydrolysis at the liver and other tissues. It is used as an anticoagulant in a variety of situations, including thromboembolic disorders, stroke prevention in atrial fibrillation, and therapy in vein thrombosis.

Chemische Eigenschaften

Off-White Amorphous Solid

Definition

ChEBI: A member of the class of azetidines that is melagatran in which the carboxylic acid group has been converted to the corresponding ethyl ester and in which the amidine group has been converted to the corresponding amidoxime. A prodrug for melagatran, ximela atran was the first orally available direct thrombin inhibitor to be brought to market as an anticoagulant, but was withdrawn in 2006 following reports of it causing liver damage.

EXANTA Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


EXANTA Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 66)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054
trendseenbio@gmail.com China 11681 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501
product@acmec-e.com China 33338 58
Wuhan Jingkang en Biomedical Technology Co., Ltd
+8613720134139
orders@jknbiochem.com China 5221 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580
cooperation@kean-chem.com China 40066 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131957 58
Changsha Fuzhen Biotechnology Co.,LTD 13823398779 18670069958
3062105966@qq.com China 3262 58

  • N-[(1R)-1-Cyclohexyl-2-[(2S)-2-[[[[4-[(hydroxyamino)iminomethyl]phenyl]methyl]amino]carbonyl]-1-azetidinyl]-2-oxoethyl]glycine Ethyl Ester
  • EXANTA
  • Glycine, N-[(1R)-1-cyclohexyl-2-[(2S)-2-[[[[4-[(hydroxyaMino)iMinoMethyl]phenyl]Methyl]aMino]carbonyl]-1-azetidinyl]-2-oxoethyl]-, ethyl ester
  • Exanta (XiMelagatran)
  • Ethyl 2-[[(1R)-1-Cyclohexyl-2-[(2S)-2-[[4-(N'-Hydroxycarbamimidoyl)Phenyl]Methylcarbamoyl]Azetidin-1-Yl]-2-Oxoethyl]Amino]Acetate Ximelagatran
  • Ethyl 2-[[(1R)-1-Cyclohexyl-2-[(2S)-2-[[4-(N'-Hydroxycarbamimidoyl)Phenyl]Methylcarbamoyl]Azetidin-1-Yl]-2-Oxoethyl]Amino]Acetate Ethyl 2-[[(1R)-1-Cyclohexyl-2-[(2S)-2-[[4-(N'-Hydroxycarbamimidoyl)Phenyl]Methylcarbamoyl]Azetidin-1-Yl]-2-Oxo-Ethyl
  • XIMELEGATRAN
  • EXANTA/XIMELEGATRAN
  • H 376/95
  • CS-1834
  • Exanta (TN)
  • EXANTA; EXARTA; H 376-95; EXANTA (TN); H 376/95; H 37695; XIMELAGATRAN [USAN:INN]; XIMELAGATRAN (JAN/USAN/INN)
  • Exarta
  • Ximelagatran (JAN/USAN/INN)
  • Ximelagatran [USAN:INN]
  • Ximelagatran (H 376/95)
  • Inhibitor,inhibit,Ximelagatran,Thrombin
  • Ethyl ((R)-1-cyclohexyl-2-((S)-2-((4-(N-hydroxycarbamimidoyl)benzyl)carbamoyl)azetidin-1-yl)-2-oxoethyl)glycinate
  • ethyl 2-{[(1R)-1-cyclohexyl-2-[(2S)-2-({[4-(N-hydroxycarbamimidoyl)phenyl]methyl}carbamoyl)azetidin-1-yl]-2-oxoethyl]amino}acetate
  • 192939-46-1
  • C24H35N5O5
  • Aromatics
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Aromatics Compounds
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