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1,2-DIHYDRO-2-[(2-METHYL-4-PYRIDINYL)METHYL]-1-OXO-8-(2-PYRIMIDINYLMETHOXY)-4-(3,4,5-TRIMETHOXYPHENYL)-2,7-NAPHTHYRIDINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE

1,2-DIHYDRO-2-[(2-METHYL-4-PYRIDINYL)METHYL]-1-OXO-8-(2-PYRIMIDINYLMETHOXY)-4-(3,4,5-TRIMETHOXYPHENYL)-2,7-NAPHTHYRIDINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE Struktur
324572-92-1
CAS-Nr.
324572-92-1
Englisch Name:
1,2-DIHYDRO-2-[(2-METHYL-4-PYRIDINYL)METHYL]-1-OXO-8-(2-PYRIMIDINYLMETHOXY)-4-(3,4,5-TRIMETHOXYPHENYL)-2,7-NAPHTHYRIDINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE
Synonyma:
T-0156;T0156HCl;T 0156 HYDROCHLORIDE;1,2-Dihydro-2-((2-methyl-4-pyridinyl)methyl)-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine;2,7-Naphthyridine-3-carboxylic acid, 1,2-dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-, methyl ester;2-(2-METHYLPYRIDIN-4-YL)METHYL-4-(3,4,5-TRIMETHOXYPHENYL)-8-(PYRIMIDIN-2-YL)METHOXY-1,2-DIHYDRO-1-OXO-2,7-NAPHTHYRIDINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE;1,2-DIHYDRO-2-[(2-METHYL-4-PYRIDINYL)METHYL]-1-OXO-8-(2-PYRIMIDINYLMETHOXY)-4-(3,4,5-TRIMETHOXYPHENYL)-2,7-NAPHTHYRIDINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE;2-(2-Methylpyridin-4-yl)methyl-4-(3,4,5-trimethoxyphenyl)-8-(pyrimidin-2-yl)methoxy-1,2-dihydro-1-oxo-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride
CBNumber:
CB7774753
Summenformel:
C31H29N5O7
Molgewicht:
583.59
MOL-Datei:
324572-92-1.mol

1,2-DIHYDRO-2-[(2-METHYL-4-PYRIDINYL)METHYL]-1-OXO-8-(2-PYRIMIDINYLMETHOXY)-4-(3,4,5-TRIMETHOXYPHENYL)-2,7-NAPHTHYRIDINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE Eigenschaften

Siedepunkt:
779.1±60.0 °C(Predicted)
Dichte
1.329±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: soluble
pka
5.53±0.10(Predicted)
Farbe
white

Sicherheit

Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 22-26-36
WGK Germany  3

1,2-DIHYDRO-2-[(2-METHYL-4-PYRIDINYL)METHYL]-1-OXO-8-(2-PYRIMIDINYLMETHOXY)-4-(3,4,5-TRIMETHOXYPHENYL)-2,7-NAPHTHYRIDINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Biologische Aktivit?t

Potent and selective inhibitor of phosphodiesterase type 5 (PDE5); more selective than sildenafil (IC 50 values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1-4 respectively). Selective over 30 other enzymes and receptors (IC 50 > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum. Active in vivo .

1,2-DIHYDRO-2-[(2-METHYL-4-PYRIDINYL)METHYL]-1-OXO-8-(2-PYRIMIDINYLMETHOXY)-4-(3,4,5-TRIMETHOXYPHENYL)-2,7-NAPHTHYRIDINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

1,2-DIHYDRO-2-[(2-METHYL-4-PYRIDINYL)METHYL]-1-OXO-8-(2-PYRIMIDINYLMETHOXY)-4-(3,4,5-TRIMETHOXYPHENYL)-2,7-NAPHTHYRIDINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 20)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8447 60
TargetMol Chemicals Inc. 4008200310
 marketing@tsbiochem.com China 24644 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627
 customer_service@efebio.com China 11974 58

324572-92-1()Verwandte Suche:

  • 1,2-DIHYDRO-2-[(2-METHYL-4-PYRIDINYL)METHYL]-1-OXO-8-(2-PYRIMIDINYLMETHOXY)-4-(3,4,5-TRIMETHOXYPHENYL)-2,7-NAPHTHYRIDINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE
  • T-0156
  • T 0156 HYDROCHLORIDE
  • 1,2-Dihydro-2-((2-methyl-4-pyridinyl)methyl)-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine
  • T0156HCl
  • 2-(2-Methylpyridin-4-yl)methyl-4-(3,4,5-trimethoxyphenyl)-8-(pyrimidin-2-yl)methoxy-1,2-dihydro-1-oxo-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride
  • 2-(2-METHYLPYRIDIN-4-YL)METHYL-4-(3,4,5-TRIMETHOXYPHENYL)-8-(PYRIMIDIN-2-YL)METHOXY-1,2-DIHYDRO-1-OXO-2,7-NAPHTHYRIDINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE
  • 2,7-Naphthyridine-3-carboxylic acid, 1,2-dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-, methyl ester
  • 324572-92-1
  • C31H29N5O7HCl
  • Phosphodiesterase Inhibitors
  • G Proteins and Cyclic Nucleotides
  • Cyclic Nucleotide Metabolism
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
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