MONASTROL
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- CAS-Nr.
- 254753-54-3
- Englisch Name:
- MONASTROL
- Synonyma:
- CS-2432;Monastrol（b）;(S)-Monastrol;O-(4-Hydroxy-3-iodophenyl)-3;Monastrol - CAS 254753-54-3 - Calbiochem;6-METHYL-4-(3-HYDROXYPHENYL)-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE;1,2,3,4-TETRAHYDRO-4-(3-HYDROXYPHENYL)-6-METHYL-2-THIOXO-5-PYRIMIDINECARBOXYLIC ACID, ETHYL ESTER;ethyl (4S)-4-(3-hydroxyphenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate;4-(3-HYDROXYPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDRO-4H-PYRIMIDIN-5-CARBOXYLIC ACID ETHYL ESTER;5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-, ethyl ester, (4S)-
- CBNumber:
- CB7745337
- Summenformel:
- C14H16N2O3S
- Molgewicht:
- 292.35
- MOL-Datei:
- 254753-54-3.mol
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MONASTROL Eigenschaften
- Schmelzpunkt:
- 185-185.9 °C(lit.)
- Siedepunkt:
- 441.3±55.0 °C(Predicted)
- Dichte
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: 100 mg/mL
- Aggregatzustand
- White solid
- pka
- 9.63±0.10(Predicted)
- Farbe
- white to off-white
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
- CAS Datenbank
- 254753-54-3(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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MONASTROL Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Crystalline Solid
Verwenden
Monastrol has been used:
- to treat MDA-MB-231 cells as a non-microtubule-targeting agent
- as a antineoplastic agent, to treat mouse myeloma cell line SP 2/0, to induce apoptosis and to elucidate the role of metabotropic glutamate receptor 3 (Grm3) in apoptosis
- as an inhibitor of pteridine reductase in GFP-transfected promastigotes infected macrophages for flow cytometer-based growth inhibition assay and to evaluate anti-leishmanial activity of Leishmania donovani hamster model in vivo
Biologische Aktivit?t
Potent, cell-permeable, small molecule mitosis inhibitor that does not interact with tubulin. Arrests cells in mitosis and specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein required for mitotic spindle formation and maintenance (IC 50 = 14 μ M).
MONASTROL Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
MONASTROL Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 66)Lieferanten
254753-54-3()Verwandte Suche:
- 4-(3-HYDROXYPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDRO-4H-PYRIMIDIN-5-CARBOXYLIC ACID ETHYL ESTER
- 6-METHYL-4-(3-HYDROXYPHENYL)-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE
- 1,2,3,4-TETRAHYDRO-4-(3-HYDROXYPHENYL)-6-METHYL-2-THIOXO-5-PYRIMIDINECARBOXYLIC ACID, ETHYL ESTER
- Monastrol - CAS 254753-54-3 - Calbiochem
- CS-2432
- 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-, ethyl ester, (4S)-
- O-(4-Hydroxy-3-iodophenyl)-3
- Monastrol（b）
- (S)-Monastrol
- ethyl (4S)-4-(3-hydroxyphenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate
- 254753-54-3
- C14H16N2O3S
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- Cell Cycle
- Cell Cycle Regulators
- Apoptosis and Cell Cycle
- All Inhibitors
- Inhibitors
