CHPG
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- CAS-Nr.
- 170846-74-9
- Englisch Name:
- CHPG
- Synonyma:
- CHPG;(RS)-2-CHLORO-5-HYDROXYPHENYLGLYCINE;α-amino-2-chloro-5-hydroxybenzeneacetic acid;Benzeneacetic acid, α-amino-2-chloro-5-hydroxy-;(RS)-2-chloro-5-hydroxyphenylglycine α-amino-2-chloro-5-hydroxybenzeneacetic acid;α-Amino-2-chloro-5-hydroxybenzeneacetic acid, (RS)-2-Chloro-5-hydroxyphenylglycine
- CBNumber:
- CB7723281
- Summenformel:
- C8H8ClNO3
- Molgewicht:
- 201.61
- MOL-Datei:
- 170846-74-9.mol
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CHPG Eigenschaften
- Siedepunkt:
- 407.3±45.0 °C(Predicted)
- Dichte
- 1.531±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ≥10mg/mL
- Aggregatzustand
- solid &_& white solid
- pka
- 1.61±0.10(Predicted)
- Farbe
- white
CHPG Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
(R,S)-CHPG is a potent and selective agonist at metabotropic glutamate receptor 5 (mGluR5). In CHO cells, it had an EC
50 of 750 μM for calcium mobilization in mGluR5a-expressing cells but was inactive in mGluR1a-expressing cells. In transfected HEK293 cells, (R,S)-CHPG bound mGluR1a and mGluR5a (K
is = 0.9 and 3.9 μM, respectively) but not ionotropic glutamate receptors. It reduced oxidative stress and inflammatory markers in cultured BV-2 microglial cells. In mouse models of traumatic brain injury, it reduced lesion volume, improved sensorimotor deficits in the beam walk test, and improved spatial memory in the Morris water maze.
Verwenden
CHPG is a selective mGluR-5 agonist.
Biologische Aktivit?t
A selective mGlu 5 metabotropic glutamate receptor agonist, completely inactive at mGlu 1a receptors expressed in CHO cells. Active in vivo .
CHPG Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
CHPG Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 42)Lieferanten
- α-Amino-2-chloro-5-hydroxybenzeneacetic acid, (RS)-2-Chloro-5-hydroxyphenylglycine
- (RS)-2-chloro-5-hydroxyphenylglycine α-amino-2-chloro-5-hydroxybenzeneacetic acid
- α-amino-2-chloro-5-hydroxybenzeneacetic acid
- (RS)-2-CHLORO-5-HYDROXYPHENYLGLYCINE
- CHPG
- Benzeneacetic acid, α-amino-2-chloro-5-hydroxy-
- 170846-74-9
- Glutamate receptor
