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FORTUNELLIN

FORTUNELLIN Struktur
20633-93-6
CAS-Nr.
20633-93-6
Englisch Name:
FORTUNELLIN
Synonyma:
FORTUNELLIN;ACACETIN-7-NEOHESPERIDOSIDE;ACACETIN-7-O-NEOHESPERIDOSIDE;4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-
CBNumber:
CB7713662
Summenformel:
C28H32O14
Molgewicht:
592.55
MOL-Datei:
20633-93-6.mol

FORTUNELLIN Eigenschaften

Schmelzpunkt:
193-198°C
Siedepunkt:
888.7±65.0 °C(Predicted)
Dichte
1.62±0.1 g/cm3(Predicted)
pka
6.10±0.40(Predicted)
Aggregatzustand
Solid
Farbe
Off-white to light yellow

Sicherheit

FORTUNELLIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Fortunellin is a potential anti-inflammation agent in inflammatory diseases, it targets miR-374a, which is a negative regulator of phosphatase and tensin homolog (PTEN). Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf-2 pathway regulation.

Chemische Eigenschaften

Off-white to light yellow Solid

Verwenden

Fortunellin is a flavonoid that can be isolated from kumquat (Fortunella margarita) fruit. Studies have shown that Fortunellin inhibits LPS-induced inflammation and ROS production in H9C2 cells, and also prevents fructose-induced inflammation and oxidative stress by enhancing the AMPK/Nrf2 pathway. In addition, Fortunellin has a dual role in the prevention and treatment of coronaviral disease, with antiviral activity against SARS-CoV-2 and anti-inflammatory immunomodulatory capacity in the host.

Biologische Funktion

Fortunellin (acacetin 7-O-neohesperidoside) is a citrus flavonoid isolated from kumquat fruit. Kumquat extract has attracted much attention recently for its beneficial effects on human health, which include antitumor, antioxidant and anti-inflammatory characteristics . The beneficial effects of flavonoids on IBD have been confirmed in many studies. However, although fortunellin is the main flavonoid in kumquat, there is a lack of information on its alleviation of IBD.

Mechanism of action

Fortunellin is a citrus flavonoid that is a potential anti-inflammation agent in inflammatory diseases. Fortunellin ameliorated colitis symptoms, including excessive inflammation and oxidative stress. Fortunellin decreased epithelial cell apoptosis through inhibiting PTEN expression in colitis. Fortunellin-induced downregulation of PTEN could be counteracted by miR-374a depletion. Moreover, knockdown of miR-374a in vivo partly inhibited the effects of fortunellin on rat colitis.

FORTUNELLIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


FORTUNELLIN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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20633-93-6()Verwandte Suche:


  • ACACETIN-7-NEOHESPERIDOSIDE
  • ACACETIN-7-O-NEOHESPERIDOSIDE
  • FORTUNELLIN
  • 4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-
  • 20633-93-6
  • C28H32O14
  • Tri-substituted Flavones
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