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CYP1A1

CYP1A1 Struktur
CAS-Nr.
Englisch Name:
CYP1A1
Synonyma:
CP12;P450-3;CYP1A1;CYP1A1 YR (HUMAN);Cytochrome P450 human;CYP1A1 MICROSOMES HUMAN;Mouse Anti-CYP1A1 antibody;CYTOCHROME P450 1A1 (HUMAN);Anti-Cyp1a2 antibody produced in goat;CYTOCHROME P450 ISOZYME MICROSOMES HUMAN
CBNumber:
CB7670943
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

CYP1A1 Eigenschaften

storage temp. 
−70°C
Aggregatzustand
buffered aqueous solution

Sicherheit

S-S?tze: 23-24/25
WGK Germany  1

CYP1A1 Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

The CYP1A1 (also called aromatic hydrocarbon hydroxylase) is expressed primarily in extrahepatic tissues, small intestine, placenta, skin, and lung as well as in the liver in response to the presence of CYP1A1 inducers, such as PAHs (i.e., in cigarette smoke and the carcinogen 3-methylcholanthrene), α-naphthoflavone (a noncarcinogenic inducer related to dietary flavones), and indole-3-carbinol (found in Brussel sprouts and related vegetables). The CYP1A1 metabolizes a range of PAHs, including a large number of procarcinogens and promutagens. Diethylstilbestrol and 2- and 4-hydroxyestradiol (catecholestrogens) are oxidized by CYP1A1 to their quinone analogues, which normally are reduced to inactive metabolites. In the absence of a detoxifying reduction step, however, the quinones may accumulate and initiate carcinogenic processes or cell death by covalently damaging DNA or cellular proteins. Interindividual variation in the inducible expression of CYP1A1 might be related to a genetic difference in aromatic hormone (Ah) receptor expression, which could explain differences in individual susceptibility to cigarette smoke–induced lung cancer.

Biochem/physiol Actions

Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Some isoforms have narrow substrate specificity, while others are promiscuous.

Mechanism of action

The mechanism for the induction of the CYP1A1 gene begins with binding of the inducing agents to a cytosolic receptor protein, the Ah receptor, which is translocated to the nucleus and binds to the DNA of the CYP1A1 gene, thus enhancing its rate of transcription. The presence of the Ah receptor in hepatic and intestinal tissues may have implications beyond xenobiotic metabolism and may play a role in the induction of other genes for the control of cellular growth and differentiation. On the other hand, CYP1A1 may metabolize procarcinogens to hydroxylated inactive compounds that are not mutagenic. The question of how the bowel protects itself from ingested compounds known to be activated by CYP1A1 (i.e., PAH) remains unanswered.

CYP1A1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


CYP1A1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 17)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Huzhen Industrial Co., LTD 021-60345367 13916550749
sales@shzbio.com China 9966 58
Beijing Boorsen Biotechnology Co., Ltd 400-901-9800 18611424007
cis@bioss.com.cn China 9518 58

  • CYTOCHROME P450 1A1 (HUMAN)
  • CYTOCHROME P450 2E1 ISOZYME MICROSOMES HUMAN
  • CYTOCHROME P450 HUMAN 2E1 ISOZYME MICROSOMES
  • CYTOCHROME P450 ISOZYME MICROSOMES HUMAN
  • Anti-Cyp1a2 antibody produced in goat
  • CP12
  • cytochrome P450, family 1, subfamily A, polypeptide 2
  • P450-3
  • Cytochrome P450 human
  • CYP1A1 YR (HUMAN)
  • CYP1A1
  • CYP1A1 MICROSOMES HUMAN
  • CYTOCHROME P450 1A1 ISOZYME MICROSOMES HUMAN
  • Mouse Anti-CYP1A1 antibody
  • Cytochrome P450s (CYPs)Multi-Drug Resistance and Drug Metabolism
  • Multidrug Resistance
  • Oxidative PathwayCancer Research
  • Phase I Enzymes
  • Phase I EnzymesCancer Research
  • Xenobiotics and Drug Metabolism
  • Cell Signaling Enzymes
  • Drug and Xenobiotic Metabolism
  • Enzymes
  • Cancer Research
  • Biochemicals and Reagents
  • Proteins and Derivatives
  • Redox
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