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dBRD9

dBRD9 Struktur
2170679-45-3
CAS-Nr.
2170679-45-3
Englisch Name:
dBRD9
Synonyma:
dBRD9;DBRD09;dBRD-9|||dBRD 9;2-((2,6-Dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)(methyl)amino)-N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)acetamide;2-({[2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)phenyl]methyl}(methyl)amino)-N-{2-[2-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethoxy)ethoxy]ethyl}acetamide;Acetamide, 2-[[[4-(1,2-dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2,6-dimethoxyphenyl]methyl]methylamino]-N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-
CBNumber:
CB74667813
Summenformel:
C40H45N7O10
Molgewicht:
783.84
MOL-Datei:
2170679-45-3.mol

dBRD9 Eigenschaften

Siedepunkt:
1014.2±65.0 °C(Predicted)
Dichte
1.357±0.06 g/cm3(Predicted)
pka
10.74±0.40(Predicted)
Aggregatzustand
Solid
Farbe
Light yellow to yellow
InChIKey
AIOCFZJGGGEWDK-UHFFFAOYSA-N
SMILES
O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC=CC(NCCOCCOCCNC(=O)CN(C)CC3C(=CC(C4=CN(C)C(=O)C5=CN=CC=C45)=CC=3OC)OC)=C12

Sicherheit

dBRD9 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

dBRD9 is a potent and selective Degrader (PROTAC?) of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). dBRD9 is composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide. Does not degrade BRD4 or BRD7 at concentrations up to 5 μM. Displays antiproliferative effects in human AML cell lines.

dBRD9 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

dBRD9 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 38)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Chuchang Biotech Co., Ltd.
+undefined15623860702
 info@chuchangbiotech.com China 116 58
Shanghai finete Pharmaceutical Co., Ltd. 		+86-18221039705
CHINA 139 55
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10473 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581
 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139
 orders@jknbiochem.com China 5221 58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. +86-027-59232304 15387063101
 2881924050@qq.com China 9956 58
Changzhou Borl Biotechnology Co.,LTD 13606124132;13656121842
 luyan0021@163.com China 219 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4566 55
  • dBRD9
  • 2-((2,6-Dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)(methyl)amino)-N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)acetamide
  • Acetamide, 2-[[[4-(1,2-dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2,6-dimethoxyphenyl]methyl]methylamino]-N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-
  • DBRD09
  • dBRD-9|||dBRD 9
  • 2-({[2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)phenyl]methyl}(methyl)amino)-N-{2-[2-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethoxy)ethoxy]ethyl}acetamide
  • 2170679-45-3
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