BGC 20-1531 (hydrochloride) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

BGC 20-1531 is a potent and selective antagonist of the prostaglandin E₂ (PGE₂; ) receptor subtype 4 (EP₄) with K_i values of 11.7, >10,000, and >10,000 nM for EP₄, EP₂, and EP₃, respectively. It is selective for EP₄, exhibiting <50% inhibition at 47 ion channels, cell-surface transporters, enzymes, and nuclear receptors at a concentration of 10 μM. BGC 20-1531 antagonizes PGE₂-induced cAMP accumulation in a dose-dependent manner in HEK293 EBNA cells that stably express human EP₄ receptors. It also reverses PGE₂-induced vasorelaxation (K_b = 15.85 nM) in human middle cerebral and middle meningeal arterial rings. BGC 20-1531 prevents PGE₂-induced increases in carotid blood flow and decreases in carotid resistance with an ID₅₀ value of 5 mg/kg in dogs.

BGC 20-1531 (hydrochloride) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

BGC 20-1531 (hydrochloride) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30236	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6777	58
Shanghai Luofa Biochemical Technology Co., Ltd.	021-51111890 15317326293	sales@molnova.com	China	4195	58

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• BGC 20-1531 (hydrochloride)
• AP 1531
• BGC20-1531 (PGN-1531
• 4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride
• GTPL3380 hydrochloride
• AP-1531 hydrochloride
• BGC201531 hydrochloride(1186532615 free base),BGC 20 1531 hydrochloride(1186532 61 5 free base)
• 1962928-26-2